PKP联合四烯甲萘醌治疗绝经后女性骨质疏松性胸腰压缩骨折的疗效分析

Analysis of the efficacy of PKP combined with tetraenaphthoquinone in the treatment of osteoporotic thoracolumbar compression fracture in postmenopausal women

目的:探讨采用PKP术联合四烯甲萘醌治疗绝经后妇女骨质疏松性椎体压缩骨折的临床疗效.方法:选取2019年11月~2021年4月在我院行PKP手术治疗的绝经后骨质疏松性椎体压缩骨折的患者,根据纳入及排除标准,随机分为治疗组、对照组,对照组给予全程、规律服用碳酸钙D3颗粒、阿法骨化醇;治疗组在此基础上给予四烯甲萘醌胶囊共6个月.分别收集两组患者年龄、身高、体重及术前、术后1天、术后3月、术后6月VAS、ODI、血清骨钙素、骨密度T值、骨折椎体前缘高度比值等相关指标,运用SPSS25.0统计分析软件对上述指标进行分析,计量资料采用两样本t检验,计数资料采用卡方检验.结果:两组患者在年龄、身高、体重、术前VAS、术前ODI、术前骨钙素、术前骨密度T值、术前骨折椎体前缘高度比值差异无统计学意义;治疗组术后3月的VAS评分虽低于对照组,但差异不明显,术后6月治疗组VAS评分明显低于对照组;治疗组术后3月、6月在ODI评分明显低于对照组、骨钙素评分明显高于对照组、骨密度T值评分明显高于对照组、椎体前缘高度比评分明显高于对照组.结论:PKP术联合四烯甲萘醌的治疗方案可以有效提高骨量、减轻中远期疼痛、提高生活质量以及降低再骨折的风险.

Objective To explore the clinical effect of PKP combined with tetraenaphthoquinone in the treatment of osteoporotic vertebral compression fracture in postmenopausal women.Methods Patients with postmenopausal osteoporotic vertebral compression fracture treated by PKP operation in our department from November 2019 to April 2021 were randomly di-vided into treatment group and control group according to the inclusion and exclusion criteria.Control group was given calcium carbonate D3 granules and Alfacalcidol regularly,while treatment group was given tetraenaphthoquinone capsule for 6 months.The age,height,weight,VAS,ODI,serum osteocalcin,bone mineral density T value and the ratio of anterior edge height of fractured vertebral body were collected before operation,1 day,3 months and 6 months after operation.The above indexes were analyzed by SPSS25.0 statistical analysis software.The measurement data were tested by two-sample t test,and the counting data were analyzed by chi-square test.Results There was no significant difference in age,height,weight,preoperative VAS,preoperative ODI,preoperative osteocalcin,preoperative bone mineral density T and the ratio of anterior height of vertebral body before fracture between two groups.There was no significant difference in the ratio of anterior edge height of VAS and ODI fractures between two groups on 1 day after operation.There was no significant difference in VAS score between two groups at 3 months after operation,but the difference was statistically significant at 6 months after operation.The values of ODI,osteocalcin,bone mineral density T and the ratio of anterior edge height of vertebral body in the treatment group and the control group were less than 0.05 at 3 and 6 months after operation,and the difference was statistically significant.Conclusion The treatment of PKP combined with tetraenaphthoquinone can effectively increase bone mass,relieve medium-and long-term pain,improve quality of life and reduce the risk of re-fracture.