临床病例讨论 第495例——青年女性-高雄激素血症-严重胰岛素抵抗

The 495th case:young female-hyperandrogenemia-severe insulin resistance

患者女性, 22岁。自青春期起逐渐出现多毛、黑棘皮征、阴蒂增大及月经紊乱等临床表现。曾多次查雄激素水平明显升高。我院住院期间发现存在严重胰岛素抵抗、糖尿病。胰岛素受体基因检测提示存在致病性突变, 诊断为A型胰岛素抵抗综合征。予二甲双胍治疗后患者黑棘皮征有明显缓解, 血糖控制满意, 月经周期恢复。

A 22-year-old female has complained of hirsutism,acanthosis nigricans,enlarged clitoris,and menstrual disorders since puberty.Laboratory examinations revealed hyperandrogenemia.Severe insulin resistance and diabetes were found during hospitalization in our hospital.She was diagnosed with type A insulin resistance syndrome finally.After treatment with metformin,the acanthosis nigricans was significantly relieved,blood glucose was controlled satisfactorily,and the menstrual cycle was restored.