千金藤素抗新冠病毒研究进展

Progress in the study of antiviral activity of cepharanthine against SARS-CoV-2

千金藤素是来自传统中药千金藤的一种生物碱,是双苄基异喹啉生物碱家族的一员,临床中主要用于白细胞减少症等疾病。近来,千金藤素抗新冠病毒的研究受到广泛关注,作为千金藤素抗新冠病毒作用的原创发现者,我们简要总结了千金藤素抗新冠病毒的重要研究进展,包括千金藤素抗新冠病毒活性的发现和验证,千金藤素抗新冠病毒机制研究进展以及临床试验进展。

As a member of the dibenzyl isoquinoline alkaloid family,cepharathine is an alkaloid from the traditional Chinese medicine cepharathine,which is mainly used for treatment of leukopenia and other diseases.Recent studies of the inhibitory effect of cepharathine against SARS-CoV-2 have attracted widespread attention and aroused heated discussion.As the original discoverer of the anti-SARS-CoV-2 activity of cepharanthine,here we briefly summarize the discovery of cepharanthine and review important progress in relevant studies concerning the discovery and validation of anti-SARS-CoV-2 activity of cepharathine,its antiviral mechanisms and clinical trials of its applications in COVID-19 therapy.