新型冠状病毒感染相关眼后节病变的研究现况

Ocular posterior segment lesions related with novel coronavirus infection

在大量新型冠状病毒(SARS-CoV-2)感染相关病例中,除结膜、角膜等眼表感染外,发生眼后节感染相关病变者逐渐增多。目前观察到的SARS-CoV-2眼后节感染相关病变主要表现为眼底缺血、出血等。病毒通过直接感染、血管源性或神经源性感染三种途径进入细胞并通过炎性反应、眼底血管血栓形成等效应引起患者视力损伤。大量重症患者出现的眼底病变提示了眼底检查在评估全身病变严重程度的价值,同时也提示及时对COVID-19患者进行眼底检查对疾病预后及远期并发症评估具有重要意义。(国际眼科纵览,2022,46:167-172)

Among the large number of cases associated with novel coronavirus(SARS-CoV-2)infection,some cases involving structural lesions of the posterior segment of the eye have also been observed in addition to the more commonly reported ocular surface infections such as conjunctiva and cornea.As the virus continues to wreak havoc worldwide,the number of SARS-CoV-2 infected patients with posterior segment lesions of the eye is gradually increasing,and the main manifestations of SARS-CoV-2 posterior segment infection observed so far are fundus ischaemia and haemorrhage.The virus enters the cells through direct infection,vasculogenic or neurogenic infection and causes damage to the patients'vision through effects such as inflammatory responses and fundus vascular thrombosis.It is suggested that the value of fundus examination in assessing the severity of systemic lesions and the importance of timely fundus examination in COVID-19 patients for the prognosis of the disease and the assessment of long-term complications should be cherished.(Int Rev Ophthalmol,2022,46:167-172)