2018年-2021年义乌市12岁以下儿童诺如病毒感染性腹泻检测结果分析

Analysis of detection results of norovirus diarrhea in children under 12 years old in Yiwu City from 2018 to 2021

目的 分析就诊于义乌市几个哨点医院12岁以下儿童腹泻病例被诺如病毒感染的流行病学特征,为义乌市诺如病毒防控提供科学依据。方法 采用胶体金法检测2018年1月-2021年11月本院1 866例腹泻患者粪便样本中诺如病毒GⅠ、GⅡ基因型。结果 1 866份样本中,诺如病毒阳性率为15. 81%(295/1 866),295份诺如病毒阳性样本中主要基因型是GⅡ,占比93. 22%(275/295)。诺如病毒第四季度阳性率最高(22. 31%),其次是第三季度(17. 56%);诺如病毒阳性率与儿童性别无关,但是与儿童年龄段有关,其中3. 1岁~6岁幼托阶段诺如病毒阳性率最高(18. 48%),其次是6. 1岁~9岁小学低年级阶段(18. 16%)。结论 义乌市12岁以下儿童腹泻病例诺如病毒检测基因型主要是GⅡ型,秋冬季节是发病高峰期,幼托阶段和小学低年级阶段是诺如病毒易感年龄。

Objective To analyze the epidemiological characteristics of norovirus infection of diarrhea cases in children under 12 years old who have been admitted to several sentinel hospitals in Yiwu City,so as to provide scientific basis for the prevention and control of norovirus in Yiwu City.Methods Norovirus GI and GII genotypes were detected by colloidal gold method after detecting 1866 fecal samples of patients with diarrhea in our hospital during January 2018 to November 2021.Results Among the 1866 samples,the positive rate of norovirus was 15.81%(295/1866).The main genotype of 295 norovirus positive samples was GII,accounting for 93.22%(275/295).The positive rate was the highest in the fourth season(22.31%),followed by 17.56%in the third season.The positive rate of norovirus was not related to the gender of children,but was related to the age of the children.The positive rate of norovirus was the highest between 3.1 years old and 6 years old(18.48%),followed by that between 6.1 years old and 9 years old(18.16%).Conclusion The genotype of norovirus detection in children with diarrhea under 12 years old in Yiwu city is mainly G U.The autumn and winter seasons are the peak period of disease.Nursery and lower grades pupils are in the age of norovirus susceptibility.