阿来替尼药物不良反应文献分析

Literature Analysis of Adverse Drug Reactions Induced by Alectinib

目的分析阿来替尼药物不良反应(adverse drug reactions,ADRs)的发生规律,为临床合理用药提供文献依据。方法检索截止到2022年2月中国知网数据库(CNKI)、万方、维普及Pubmed、Medline等数据库关于阿来替尼的文献。对文献进行整理,分析文献发表的分布情况,并对其不良反应发生时间、累及系统、临床表现及转归等信息进行分析汇总。结果共纳入文献28篇,个案32例。首次发表关于阿来替尼ADRs的个案报道是2015年。患者中男性12例,女性20例,平均年龄为(62.9±10.5)岁。所致ADRs主要累及呼吸系统(28.2%),其次为消化系统、皮肤、泌尿系统等。结论阿来替尼在用药的过程中要加强监测,做好跟踪随访和记录,发现ADRs及时处理,避免病情加重。

OBJECTIVE To analyze the clinical manifestations,characteristics,regularity and outcomes of adverse drug reactions(ADRs)of aletinib in order to provide reference for clinicians to use the drug safely.METHODS CNKI,Wanfang,VIP,PubMed,MEDLINE were searched to collect the ADR case reports of alectinib from the date of establishment until February 2022.In retrospec⁃tive study,the patient′s information,occurrence time of ADR,involved systems,clinical manifestations,and outcome were statistically analyzed.RESULTS A total of 28 articles were included,involving 32 cases.The first case published in 2015.Twelve cases were males and 20 cases were females.The mean age of the patients was(62.9±10.5)years old.Alectinib⁃induced ADRs were mainly respiratory(28.2%),followed by urinary system,digestive system and skin damage.CONCLUSION It is necessary to strengthen the monitoring,follow⁃up and record in the course of medication of aletinib,and deal with ADRs in time to avoid aggravation of the disease.