联合用药对不稳定型心绞痛的治疗效果

Effect of drug combination on unstable angina pectoris

目的分析辅酶Q10联合法舒地尔治疗冠心病不稳定型心绞痛的效果。方法将88例冠心病不稳定型心绞痛患者依据治疗方案不同分为对照组和观察组。对照组43例予以法舒地尔治疗,观察组45例在对照组基础上联合辅酶Q10治疗。比较两组疗效、治疗前与治疗15 d后症状改善情况(心绞痛发作频率、持续时间)、血清炎性因子水平(白介素-6、肿瘤坏死因子-α)、免疫功能指标(CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+))及不良反应发生率。结果治疗15 d后,观察组治疗总有效率高于对照组;心绞痛发作频率低于对照组,心绞痛持续时间短于对照组(P<0.05);观察组血清白介素-6、肿瘤坏死因子-α水平低于对照组(P<0.05);观察组CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)水平高于对照组(P<0.05);两组不良反应发生率比较,P>0.05。结论辅酶Q10联合法舒地尔治疗冠心病不稳定型心绞痛疗效显著,能有效改善患者临床症状,且安全性高。

Objective To analyze the efficacy of coenzyme Q10 combined with fasudil in the treatment of unstable angina pectoris of coronary heart disease.Methods 88 patients with unstable angina pectoris of coronary heart disease treated in our hospital were divided into the control group and the observation group according to different therapeutic regimen.43 cases in the control group were treated with fasudil,and 45 cases in the observation group was treated with coenzyme Q10 on the basis of the control group.The efficacy,symptom improvement(frequency and duration of angina pectoris),serum inflammatory factors levels(interleukin-6 and tumor necrosis factor-α),immune function indexes(CD_(3)^(+),CD_(4)^(+),CD_(4)^(+)/CD_(8)^(+)) before treatment and 15 days after treatment and incidence of adverse reactions were compared between the two groups.Results After 15 days of treatment,the total effective rate in the observation group was significantly higher than that in the control group(P<0.05).The attack frequency of angina pectoris was lower than that in the control group,and the duration of angina pectoris was shorter than that in the control group(P<0.05).The serum interleukin-6 and tumor necrosis factor-αlevels were significantly lower than those in the control group(P<0.05).The levels of CD_(3)^(+),CD_(4)^(+),CD_(4)^(+)/CD_(8)^(+) in the observation group were significantly higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of coenzyme Q10 and fasudil in the treatment of angina pectoris of coronary heart disease is effective and can effectively improve the clinical symptoms of patient with high safety.