联合用药对急性冠脉综合征PCI术后患者的效果观察

Observation on the effect of drug combination on acute coronary syndrome patients after PCI

目的探究阿司匹林联合替格瑞洛对急性冠脉综合征患者PCI术后的治疗效果。方法选取我院收治的经皮冠状动脉介入(PCI)治疗的急性冠状动脉综合征(ACS)患者113例,随机数字表法分为两组。对照组56例给予阿司匹林肠溶片及硫酸氢氯吡格雷进行治疗,观察组57例给予阿司匹林肠溶片及替格瑞洛治疗。观察两组左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、心脏指数(CI)、心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)水平、血小板最大聚集率(MPAR)、纤维蛋白原(FIB)、高敏C反应蛋白(hs-CRP)、血清性白细胞分化抗原40配体(sCD40L)水平及不良事件发生情况。结果治疗后观察组LVEF、CI、MPAR、FIB高于对照组,LVEDD、cTnI、CK-MB、hs-CRP、s CD40L水平、不良事件发生率低于对照组(P<0.05)。结论替格瑞洛联合阿司匹林肠溶片应用于ACS患者PCI术后治疗,可有效降低炎症反应,改善凝血功能,降低心血管不良事件发生率,促进心功能恢复。

Objective To explore the effect of aspirin combined with ticagrelor on acute coronary syndrome patients after PCI.Methods 113 cases of acute coronary syndrome(ACS)patients who underwent percutaneous coronary intervention(PCI)treatment in our department were selected and randomly divided into the observation group and the control group.56 patients in the control group were treated with aspirin enteric-coated tablets and clopidogrel bisulfate,and 57 patients in the observation group were treated with aspirin enteric-coated tablets and ticagrelor.The left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),cardiac index(CI),cardiac troponin I(cTnI),creatine kinase isoenzyme(CK-MB)level,maximum platelet aggregation rate(MPAR),fibrinogen(FIB)level,high sensitivity C-reactive protein(hs-CRP)and serum leukocyte differentiation antigen 40 ligand(sCD40L)level and adverse events were compared between the two groups.Results After treatment,the LVEF,CI,MPAR,FIB in the observation group were higher than those in the control group;the LVEDD,cTnI,CK-MB,hs-CRP,sCD40L level and the incidence of adverse events were lower than those in the control group(P<0.05).Conclusion Ticagrelor combined with aspirin enteric-coated tablets can effectively reduce inflammation,improve blood coagulation,reduce the incidence of adverse cardiovascular events and promote the recovery of heart function in the treatment of ACS patients after PCI.