双重食欲素受体拮抗剂lemborexant治疗失眠障碍临床研究进展

Clinical research progress of dual orexin receptor antagonist lemborexant in the treatment of insomnia

在过去的20年中,人们对食欲素系统在调节睡眠和觉醒方面作用的了解迅速增加。lemborexant作为双重食欲素受体拮抗剂已在部分国家被批准用于治疗失眠障碍,现有研究显示其安全性和耐受性与传统催眠药物相比具有显著优越性,将为临床失眠障碍的治疗提供新的手段。文中对双重食欲素受体拮抗剂lemborexant的药理学、临床疗效和安全性等方面进行综述。

In past two decades,understanding of the role of the orexin system in regulating sleep and wakefulness has increased rapidly.Lemborexant,as a dual orexin receptor antagonist,has been approved in some countries for the treatment of insomnia disorders.Existing studies have shown that its safety and tolerability are significantly superior to traditional hypnotic drugs,and it will be new option for treating insomnia disorders.This article reviews the pharmacology,clinical efficacy and safety of lemborexant.