MicroRNA-based targeting of the Rho/ROCK pathway in therapeutic strategies after spinal cord injury

Spinal cord injury(SCI)is one of the leading causes of disability and is a devastating condition that requires long-term care,reduces social productivity,and gives an immense emotional burden on patients and their fa milies.SCI frequently occurs due to traffic accidents,falls,slips,violence,sports,and medical accidents in today's society.The initial mechanical damage triggers a secondary injury cascade that induces more intractable damage(Silva et al.,2014).Secondary injury mechanisms have been postulated,including neuronal apoptosis,inflammation,oxidative stress,and excitotoxicity.