摘要
Mitochondria are well cha racterized by their fundamental functions in regulating cellular homeostasis,including energy and iron metabolism.These functions are essential in neurons with high metabolic demands and elongated neuronal processes.Mitochondria dynamically change morphology,localization,and activity to match neurons'spatial and temporal demands.Mitochondrial dysfunctions have been associated with many neurological disorders.
基金
supported by grants from the National Institute on Aging(AG063766and AG028740 to RX,AG066654 to SMH,T32AG062728 to TM)
the American Cancer Society(RSG-17-171-01-DMC to RX)
the American Federation for Aging Research(AGR DT07-2502019 and AGR DTD 09-15-2021 to SMH)。
