人工真皮联合臭氧大自血疗法对慢性难愈合创面的疗效

Efficacy trial of artificial dermis combined with ozone autoblood therapy in chronic difficult-to-heal wounds

目的探讨人工真皮联合臭氧大自血疗法治疗慢性难愈合创面的效果及安全性,为其临床推广提供依据。方法选取2017年12月至2021年3月收治的40例慢性难愈合创面患者随机分为实验组和对照组,对照组给予常规负压吸引联合纱布外敷治疗,实验组给予人工真皮联合臭氧大自血疗法治疗,比较两组患者创面瘢痕评分、创面愈合时间、植皮存活率、痛觉/触觉恢复时间、血管化周期、治疗费用、住院时间、随访指标。结果实验组患者创面瘢痕评分较对照组患者显著降低(P<0.05),创面愈合时间、痛觉/触觉恢复时间、血管化周期较对照组患者显著缩短,植皮存活率显著提高(P<0.05),治疗费用、住院时间显著低于对照组(P<0.05),皮片破损率、不良反应发生率分别为0.00%、5.00%,较对照组患者20.00%、30.00%显著降低(P<0.05);结论人工真皮联合臭氧大自血疗法治疗慢性难愈合创面可显著提高临床效果,缩短创面愈合时间,减少植皮失败,促进创面愈合,且降低治疗费用,减轻患者经济负担,值得推广。

Objective To explore and analyze the effect and safety of artificial dermis combined with ozone autoblood therapy on chronic refractory wounds,and provide a basis for its clinical promotion.Methods 40 chronic patients admitted from December 2017 to March 2021 Patients with difficult-to-heal wounds were divided into experimental group and control group.The control group was treated with conventional vacuum suction combined with gauze topical treatment,and the experimental group was treated with artificial dermis combined with ozone autohemotherapy.The wound scar score,wound healing time,skin graft survival rate,pain/touch recovery time,vascularization cycle,treatment cost,hospital stay,and follow-up indicators were compared between the two groups.Results The wound scar score of the experimental group was significantly lower than that of the control group(P<0.05),wound healing time,pain/touch recovery time and vascularization cycle were significantly lower than those in the control group,the skin graft survival rate was significantly improved(P<0.05).The treatment cost and length of hospital stay were significantly lower than those of the control group(P<0.05),and the skin graft damage rate and the incidence of adverse reactions were 0.00%and 5.00%,respectively,which were significantly lower than those of the control group(20.00%and 30.00%)(P<0.05).Conclusion Artificial dermis combined with ozone autohemotherapy in the treatment of chronic refractory wounds can significantly improve the clinical effect,shorten the wound healing time,reduce the failure of skin grafting,promote wound healing,and reduce the treatment cost and the economic burden of patients,which is worthy of promotion.