PET/CT在多发性骨髓瘤中的临床应用及进展

Clinical application and progress of PET/CT in multiple myeloma

多发性骨髓瘤(MM)是一种浆细胞恶性增殖性疾病,异常增生的克隆性浆细胞可累及骨骼系统或髓外,进而造成组织或器官损伤。^(18)F-氟脱氧葡萄糖(FDG)PET/CT可以监测全身葡萄糖代谢,故已成为评估MM病况的主要影像学方法之一。笔者就^(18)F-FDG PET/CT在MM诊断、分期、疗效评估和预后预测中的临床应用作一综述,并分析了其局限性,同时,对新型分子探针在MM中的应用进行了介绍和展望,以期提高临床医师对PET/CT在MM诊疗中临床价值的认知,进一步发挥PET/CT在MM临床决策中的重要作用。

Multiple myeloma(MM)is a proliferous plasma cell malignancy.Abnormal proliferation of clonal plasma cells could not only involve skeletal system but also invade extramedullary and cause tissues or organs damage.^(18)F-fluorodeoxyglucose(FDG)PET/CT has become one of the most primary imaging methods for condition evaluation of MM by monitoring systemic glucose metabolism.The authors review the clinical application of ^(18)F-FDG PET/CT in the diagnosis,staging,efficacy evaluation and prognosis prediction of MM,analyze its limitations,also introduce and prospect the application of new molecular probes in MM,in order to improve the clinicians'understanding of the clinical value of PET/CT in the diagnosis and treatment of MM,and further play the essential role of PET/CT in the clinical decision-making of MM.