核受体在肿瘤放疗增敏中作用机制的研究进展

Research progress on the mechanism of nuclear receptors in tumor radiosensitization

放疗是肿瘤治疗的主要方法之一,但肿瘤存在辐射抗性,且正常组织存在辐射耐受剂量问题,两者严重影响肿瘤的放疗效果。因此,研究辐射增敏新策略以提高肿瘤细胞的辐射敏感性尤其重要。核受体是细胞内含量丰富的一类转录因子超家族,参与机体多种病理生理过程。近年来的研究结果表明,核受体及其相关配体可能参与肿瘤的放疗抵抗,因而核受体可能是肿瘤放疗增敏的新靶点。笔者总结了核受体及相关配体在肿瘤放疗增敏方面的研究进展。

Radiotherapy has become one of the main approaches in cancer treatment.However,tumor have radioresistance and normal tissues have radiation tolerant doses,both seriously affect the effect of cancer radiotherapy.It is of importance to develop radiation sensitizers to improve the radiosensitivity of tumor cells.Nuclear receptors are a kind of transcription factor superfamily,which are abundantly expressed in cells and participates in various pathophysiological processes.Recent studies have suggested that nuclear receptors and their related ligands may play important roles in tumor radioresistanace,which provide novel targets for radiosensitization.In this review,the research progress of nuclear receptors and related ligands in tumor radiosensitization is discussed.