海藻酸钠肠溶包被氧化锌微球的制备

Preparation of Sodium Alginate Enteric Coated Zinc Oxide Microspheres

针对氧化锌易被仔猪胃里的酸性胃液分解,导致饲料中的氧化锌添加量较高,对环境造成污染,长期使用反而会抑制仔猪的生长的情况,以海藻酸钠为载体,制备了海藻酸钠肠溶包被氧化锌微球。考察了各组分配比对药物粒径、收率、载药量、包封率及在胃液和肠液中释放时间的影响。结果表明,较为理想的微球的配方为:海藻酸钠、氯化钙、壳聚糖的质量分数分别为3%、3%、0.25%,氧化锌投加质量分数为10%。所制得的微球在形态、粒径、包封率、体外释放溶出的实验等方面均表现优秀,在pH为6.8的模拟肠液中,所制得微球在0.5 h内的释药量大于80%。

Zinc oxide is easy to be decomposed by acidic gastric juice in the stomach of piglets, resulting in a high amount of zinc oxide in feed, which causes pollution to the environment. Long-term use will inhibit the growth of piglets. Sodium alginate was used as a carrier to prepare sodium alginate enteric coated zinc oxide microspheres. The effects of distribution ratio on particle size, yield,drug loading, encapsulation efficiency and release time in gastric and intestinal fluids were investigated. The results showed that the ideal formulation of microspheres was as follows : the mass fractions of sodium alginate, calcium chloride and chitosan were 3%,3% and 0.25%, respectively, and the mass fraction of zinc oxide was 10%. The prepared microspheres showed excellent morphology,particle size, encapsulation efficiency, and in vitro release and dissolution experiments. In the simulated intestinal fluid with pH 6.8,the drug release of the prepared microspheres was more than 80 % within 0.5 h.