蒙古族血栓患者血栓弹力图和凝血项目的对比分析

Comparative Analysis of Thromboelastogram and Coagulation Items in Mongolian Patients with Thrombosis

目的:探讨蒙古族血栓病所致脑梗死患者年龄分布情况及血栓弹力图(TEG)与凝血四项各参数间的相关性和一致性。方法:回顾性分析2020年1月-2021年12月内蒙古民族大学附属医院收治的298例蒙古族血栓病所致脑梗死患者的年龄分布及TEG、常规凝血四项和血常规中血小板计数的结果,统计分析两种检测方法的相关性和一致性。结果:298例蒙古族血栓病所致脑梗死患者发病年龄主要集中在61-70岁,占比最高,为38.3%,其次为51-60岁,占26.8%。TEG检测的R时间与PT、APTT呈线性相关(r=0.186,r=0.152),TEG测出的K值、MA值、α-Angle与Fib呈明显的线性相关(r=-0.364,r=0.616,r=0.359),TEG测出的K值、MA值、α-Angle与P1t呈明显的线性相关(r=0.318,r=0.519,r=0.301);TEG检测的R时间与PT、APTT的Kappa值分别为0.252(P<0.001)和0.336(P<0.001);K值、MA值、α-Angle和Fib的Kappa值分别为0.265(P<0.001)、0.289(P<0.001)和0.290(P<0.001);K值、MA值、α-Angle和P1t的Kappa值分别为0.276(P<0.001)、0.285(P<0.001)和0.302(P<0.001)。结论:蒙古族血栓病所致脑梗死患者发病年龄主要集中在61-70岁,其次是51-60岁,发病年龄具有年轻化趋势;TEG与凝血四项之间呈显著相关,但一致性弱,两种方法不能互相替代。

Objective: To investigate the age distribution of Mongolian patients with cerebral infarction caused by thrombosis and the correlation and consistency between thromboelastography(TEG) and four parameters of coagulation. Methods: The age distribution of 298 Mongolian patients with cerebral infarction treated in Affiliated Hospital of Inner Mongolia Minzu University from January 2020 to December 2021 and their TEG, four items of routin coagulation and platelet count were analyzed retrospectively. The correlation and consistency of above-mentioned two detection methods were statistically analyzed. Results: The onset age of 298 Mongolian patients with cerebral infarction was mainly 61-70 years old, accounting for 38.3%, followed by 51-60 years old, accounting for 26.8%. The R time detected by TEG was linearly correlated with PT and APTT(r=0.186,r=0.152). K value, MA value and α-Angle measured by TEG was linearly correlated with Fib(r=-0.364,r=0.616,r=0.359), K value, MA value and α-Angle measured by TEG was linearly correlated with Plt(r=0.318,r=0.519,r=0.301). The R time detected by TEG was consistent with PT and APTT, and the Kappa values were 0.252(P<0.001), 0.336(P<0.001). K, MA, and α-Angle measured by TEG was consistent with Fib, the Kappa values were 0.265(P<0.001), 0.289(P<0.001) and 0.290(P<0.001), respectively;K、MA and α-Angle measured by TEG was consistent with Plt, the Kappa values were 0.276(P<0.001), 0.285(P<0.001) and 0.302(P<0.001), respectively. Conclusion: The onset age of Mongolian patients with cerebral infarction caused by thrombosis is mainly 61-70 years old, followed by 51-60 years old. The onset age shows a younger trend. There is a significant correlation between TEG and coagulation, but the consistency is weak, therefore, the two methods can not be replaced each other.