摘要
N6-甲基腺苷(m^(6)A)修饰是真核生物mRNA中最普遍的内部修饰,也存在于非编码RNA中。m^(6)A对m RNA的修饰主要发生在转录起始位点和3′-非翻译区(3′-UTR),其动态调控主要依赖m^(6)A甲基转移酶、m^(6)A去甲基化酶和m^(6)A结合蛋白。越来越多的研究发现,m^(6)A可通过各种机制调节RNA的稳定性、运输、剪接和翻译,在转录后水平调控基因表达。本文重点讨论了m^(6)A修饰在基因表达调控中的作用及其与各种疾病的关系。
N6-methyladenosine(m^(6)A) modification is the most common internal modification in eukaryotic mRNA, and also exists in non-coding RNA. The modification of mRNA by m^(6)A mainly occurs at the transcription initiation site and 3′-untranslated region(3′-UTR), and its dynamic regulation mainly depends on m^(6)A methyltransferase, m^(6)A demethylase and m^(6)A binding protein. More and more studies have revealed that m^(6)A could regulate the stability, transport, splicing and translation of mRNA through various mechanisms, and regulate gene expression at the post transcriptional level. Here we discussed the role of m^(6)A methylation in gene expression regulation and its relationship with various diseases.
作者
温媛媛
黄凯玥
史会连
吴彦池
陈园园
WEN Yuanyuan;HUANG Kaiyue;SHI Huilian;WU Yanchi;CHEN Yuanyuan(Department of Biochemistry and Molecular Biology,Nanjing Medical University,Nanjing 211166,China;Department of Infectious Diseases,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210000,China)
出处
《生命的化学》
CAS
2022年第2期275-282,共8页
Chemistry of Life
基金
国家自然科学基金项目(82070804,81903974)。
