Notch信号通路在心肌缺血损伤中的作用研究

The role of Notch signal pathway in myocardial ischemic injury

Notch信号通路是相邻细胞间分子信息交流的媒介,在心血管系统的发育和生长中起关键作用,参与了心脏发生、发育、分化、增殖、病理生理的整个过程。当心肌缺血时,该通路可通过不同路径参与调控心肌缺血损伤,包括细胞凋亡、自噬、巨噬细胞调控及缺血后心室重构等过程,在心肌缺血受损时能够发挥重要作用。本文以Notch信号通路为主线,综述了其在心肌缺血损伤方面的研究进展,以期为心肌缺血损伤的修复和寻求药物治疗靶点提供借鉴。

The Notch pathway is a mediator of the communication of molecular signals between adjacent cells,plays an extremely important role in the cardiovascular system,both during development and postnatal life.Notch signaling pathway is involved in the whole process of cardiac genesis,development,differentiation,proliferation and pathophysiology.When myocardial ischemia occurs,Notch signaling pathway is activated and participates in the regulation of myocardial ischemic injury through different pathways,including apoptosis,autophagy,macrophage regulation,and post-ischemic ventricular remodeling,etc.In this review,Notch signaling pathway is taken as the main line to explore the research progress of its mechanism of action in myocardial ischemic injury,and provides useful reference for therapy of myocardial ischemic injury and identifying therapeutic targets.