溴结构域蛋白质4调节肿瘤发展的机制

Mechanism of the bromodomain protein 4 regulating tumor development

溴结构域蛋白质4(the bromodomain protein 4,BRD4)属于溴结构域和超末端结构(the bromodomain and extra-terminal domain,BET)家族的成员,通过结合乙酰化组蛋白并调节基因表达从而参与一系列重要的生物学过程,如细胞生长、凋亡、炎症、免疫抑制等。BRD4在癌症相关的基因表达中发挥重要作用,是对抗恶性肿瘤最有希望的靶点之一,了解BRD4在肿瘤中的作用机制对于推进肿瘤研究和临床治疗具有重要意义。本文简要综述了BRD4通过调控癌症增殖与凋亡、癌症免疫抑制、癌症侵袭和转移、癌症耐药等方式来影响癌症的发展,并对BRD4通过调控某些重要蛋白质或受多种微小核糖核酸(microRNA,miRNA)的调控来影响甲状腺癌、乳腺癌、胃癌、胰腺癌、前列腺癌、卵巢癌和急性髓细胞性白血病等多种肿瘤的发展机制进行了探讨。

The bromodomain protein 4(BRD4)belongs to the bromodomain and extra-terminal domain(BET)family.By binding to acetylated histones and regulating gene expression,it participates in a series of important biological processes,such as cell growth,apoptosis,inflammation,immunosuppression,etc.BRD4 plays an important role in the expression of cancer-related genes and is one of the most promising targets for fighting malignant tumors.Understanding the mechanism of BRD4 in tumors is of great significance for promoting tumor research and clinical treatment.In this paper,we briefly review the effects of BRD4 on cancer development by regulating cancer proliferation and apoptosis,cancer immunosuppression,cancer invasion and metastasis,and cancer drug resistance.Meanwhile,we discussed BRD4 affects the development mechanism of thyroid cancer,breast cancer,stomach cancer,pancreatic cancer,prostate cancer,ovarian cancer and acute myeloid leukemia by regulating some important proteins or by a variety of microRNA.