形貌和粒径对纳米金协同超声在医药领域应用的影响

Effects of morphology and particle size of nano-gold on the synergistic application with ultrasound in the field of biomedicine

随着纳米技术的高速发展,纳米材料在医药领域的应用也日益增多。然而,纳米材料颗粒大小及形貌变化常会对其活性带来较大的影响,因此相关研究越来越多。近年来,超声作为一种临床辅助诊断、治疗的常用手段被广泛应用于医药领域,而纳米金(gold nanoparticles,AuNPs)展示出较好的声敏性。基于此,本文综述了不同形貌AuNPs协同超声在肿瘤治疗、药物递送及生物成像等方面的应用,同时,探讨了AuNPs粒径和形貌的改变对其声动力活性发挥的影响因素和作用机制。此外,总结了AuNPs与超声协同在医药领域应用中亟待解决的问题,以期为AuNPs在医药领域更广泛的使用提供新思路。

The rapid progress in nanotechnology has dramatically promoted the applications of nanomaterials in pharmaceuticals field.There are more and more relevant studies of nanomaterials because of their activities are influenced by finely tunable particle sizes and morphology.Ultrasound has been widely utilized in clinical diagnosis as well as therapeutic application around the world.Conspicuously,evidence from extensive studies suggests that gold nanoparticles(AuNPs)show good sensitive behaviors to ultrasound.This paper reviews the applications of AuNPs with different morphologies for cooperative ultrasound in tumor therapy,drug delivery and bioimaging.Moreover,the factors and mechanisms about how the morphology and size influence the AuNPs sonodynamic activities will be discussed in the last section.Furthermore,the problems that needed to be resolved in the application of AuNPs combined with ultrasound in the pharmaceutical field are summarized,in order to provide new ideas for more widely use of AuNPs in the future.