基于双模纳米探针的化学生物传感技术研究进展

Research Progress of Chemical and Biological Sensing Based on Dual-mode Nanoprobes

实际样品中化学或生物组分的多样性与复杂性特征对分析方法的准确性、选择性与检测范围提出了更高要求,然而常见的单模纳米探针难以同时满足这些目标。双模纳米探针在保留原有功能的基础上,能够提供2种独立或有关联的检测信号,不同信号之间可以相互对照、验证与补充,有效提升了方法的准确性。此外,不同双模纳米探针能够输出多样化信号,提升选择性与分析通量,有望为实际复杂样品提供更灵活高效的分析技术。依据探针输出信号的类型与特征,本文评述了近十年双模纳米探针在化学生物传感方法领域的代表性研究工作,并且提出了该领域目前面临的挑战以及未来的发展方向。

The diversity and complexity of chemical or biological components in actual samples places higher requirements on the accuracy,selectivity,and detection range of analytical methods.However,common single-mode nanoprobes are difficult to meet these objectives simultaneously.On the basis of retaining their original functions,dual-mode nanoprobes can provide two independent or related detection signals,which can be cross-referenced,verified and supplemented,thus effectively improving the accuracy of the method.In addition,different dual-mode nanoprobes can output diversified signals,improve selectivity and analytical throughput,and broaden the detection concentration range,which is expected to provide more flexible and efficient analysis techniques for complex samples.According to the types and characteristics of output signals of the probes,this paper reviews the symbolic research work done in the application of dual-mode nanoprobes in the field of chemical biosensing in the past decade,and proposes the current challenges and future development in this field.