抗阿尔茨海默病药物不同给药途径下的制剂研究进展

Research Progress on Preparations of Anti-AD Drugs under Different Administration Routes

阿尔茨海默病(Alzheimer's disease,AD)是老年人常发疾病之一,目前只能依靠长期用药来延缓病情发展。口服给药和注射给药是抗AD最普遍的治疗方式,但存在不良反应明显、给药频繁等缺点,可通过制剂新技术解决这些问题。透皮给药和鼻腔给药能避免肝脏首过效应,提高生物利用度,并有效改善药物突释引发的血药浓度波动,利用这两种给药途径可制备出更便捷高效的抗AD制剂。笔者归纳总结了不同给药途径下的制剂研究,以期为抗AD药物的制剂研发提供新的思路和参考。

Alzheimer's disease(AD)is one of the most common diseases in the elderly,which can only be delayed by long-term medication.Oral administration and intravenous administration are the most common anti-AD treatments,there are obvious adverse reactions,frequent administration and other shortcomings,which can be solved by new preparation technology.Transdermal delivery and intranasal delivery can avoid the first passeffect of liver,improve bioavailability and effectively improve the fluctuation of blood concentration caused by sudden drug release.More convenient and efficient anti-AD preparations can be prepared by these two ways.In this paper,the research of preparations under different administration routes were reviewed in order to provide new ideas and references for the research and development of anti-AD drugs.