涎腺杨氏模量值在干燥综合征诊断中的可靠性研究

Reliability of salivary gland Young’s modulus in the diagnosis of Sjogren’s syndrome

目的:评价涎腺超声杨氏模量(salivary gland Young’s modulus,SGYM)在干燥综合征(Sjogren’s syndrome,SS)诊断中的可靠性。方法:观察45例SS患者及51例健康志愿者腮腺、颌下腺、舌下腺的SGYM,评价两组受试者双侧SGYM及两组之间SGYM的差异;评价医师内部测量SGYM及医师间测量SGYM的一致性;观察受试者性别、年龄、身高、体重及腺体厚度对测量SGYM的影响。结果:无论SS组与健康组,双侧SGYM的差异均无统计学意义(P>0.05);SS组与健康组之间SGYM的差异均有统计学意义(P<0.05);医师内部及医师间测量的SGYM均具有良好的一致性,医师内部的组内相关系数为0.751~0.933,医师间测量的平均值差值有96.43%~99.02%在一致性界限及其95%置信区间以内。SGYM不受性别、年龄、身高、体重及腺体厚度的影响。结论:无论SS患者或健康志愿者,SGYM均不受检查医师和受试者自身因素影响,具有良好的可靠性。

Objective:This study aims to evaluate the reliability of salivary gland ultrasonic Young’s modulus(SGYM)in the diagnosis of Sjogren’s syndrome(SS).Methods:SGYM of parotid gland,submandibular gland and sublingual gland in 45 patients with SS and 51 healthy volunteers were observed,and the differences of SGYM between the two groups were evaluated.To evaluate the consistency of SGYM measured by physicians and between physicians,the effects of gender,age,height,weight and gland thickness on the measurement of SGYM were observed.Results:There was no significant difference in bilateral SGYM between SS group and healthy group(P>0.05).The differences of SGYM between SS group and healthy group were statistically significant(P<0.05).The SGYM measured within and among doctors has good consistency.The intra group correlation coefficient within doctors is 0.751~0.933.The differences of the average value measured between doctors were 96.43%~99.02%within the consistency limit and its 95%confidence interval.SGYM was not affected by gender,age,height,weight and gland thickness.Conclusion:Regardless of SS patients or healthy volunteers,SGYM is not affected by the factors of examiners and subjects,and has good reliability.