补阳还五汤治疗糖尿病合并短暂性脑缺血发作39例

Buyang Huanwu Decoction in the Treatment of 39 Case of Diabetes with Transient Ischemic Attack

目的探讨对糖尿病伴有短暂性脑缺血发作患者采用补阳还五汤治疗的临床效果。方法选取2018年1月1日—2020年12月31日收治的78例糖尿病伴有短暂性脑缺血发作患者;随机分为参照组(阿司匹林肠溶片)和试验组(阿司匹林肠溶片+补阳还五汤),各39例。比较2组患者治疗总有效率、TCD流速变化[椎动脉(VA)以及后循环探测基底动脉(BA)的舒张期流速(VD)、收缩期流速(VP)]、血液流变学变化[血清三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)以及空腹血糖(FPG)]。结果试验组治疗总有效率(94.87%)高于参照组(64.10%)(P<0.05)。治疗前,试验组BA的VD、VP水平同参照组比较,差异无统计学意义(P>0.05);试验组VA的VD、VP水平同参照组比较,差异无统计学意义(P>0.05);治疗后,试验组BA的VD、VP水平高于参照组(P<0.05);试验组VA的VD、VP水平高于参照组(P<0.05)。治疗前,试验组TG、TC、LDL、HDL以及FPG水平同参照组比较,差异无统计学意义(P>0.05);治疗后,试验组除HDL水平高于参照组之外,其他指标水平均低于参照组(P<0.05)。结论补阳还五汤有效应用后,观察治疗效果、TCD流速变化、血液流变学变化,改善程度显著,可促进糖尿病伴有短暂性脑缺血发作患者整体预后水平显著提升。

Objective To explore the clinical effect of Buyang Huanwu decoction in the treatment of diabetic patients with transient ischemic attack(TIA).Methods A total of 78 diabetic patients with TIA admitted to our hospital from January 1,2018 to December 31,2020 were selected for the study.They were randomly divided into the control group(enteric-dissolved aspirin tablet)and the experimental group(enteric-dissolved aspirin tablet and Buyang Huanwu decoction),with 39 cases in each group.The total effective rate of two groups of patients,TCD velocity change[VA(vertebral artery)and BA(cycle detection basilar artery)after VD(diastolic velocity),the VP(systolic velocity)],the changes of blood rheology in[TG(serum triglycerides),TC(total cholesterol),LDL(low-density lipoprotein),HDL(high density lipoprotein)and FP G(fasting blood glucose)]was compared between the two groups.Results The total effective rate of experimental group(94.87%)was higher than that of control group(64.10%)(P<0.05).Before treatment,the levels of VD and VP in experimental group were not significantly different from those in the control group(P>0.05).There were no significant differences in the levels of VD and VP in experimental group VA compared with the control group(P>00.05).After treatment,the levels of VD and VP in experimental group were higher than those in control group(P<0.05).The levels of VD and VP in experimental group VA were higher than those in control group(P<0.05).Before treatment,the levels of TG,TC,LDL,HDL and FPG in the experimental group were not significantly different from those in the control group(P>0.05).After treatment,the levels of HDL in the test group were lower than those in the control group except for those in the control group(P<0.05).Conclusion After the effective application of Buyang Huanwu decoction,the therapeutic effect,TCD flow rate change and hemorheology change are observed to be significantly improved,which can significantly improve the overall prognosis level of diabetic patients with TIA.