呼吸运动对肺癌患者三维适形调强放疗肿瘤靶区体积的影响

Effect of respiratory movement on tumor target volume of three-dimensional conformal IMRT for lung cancer patients

目的:探讨肺癌患者采用三维适形调强放疗过程中呼吸运动对肿瘤靶区体积的影响。方法:选择原发性非小细胞肺癌患者30例,均为我院2016年02月至2017年02月收治,行三维适形调强放疗,应用Eclipse 13.6版本治疗计划系统分析呼吸运动对肿瘤靶区体积和位置的影响。结果:对比肿瘤靶区在融合图像下与平静呼吸状态下的体积、融合图像下与诊断图像下的体积、平静呼吸状态下与诊断图像下的体积,不同部位病灶间均具有统计学差异(P<0.05)。结论:肺癌患者应用三维适形调强放疗方案治疗时,呼吸运动可引发肿瘤靶区体积上的改变,且伴中心坐标移位,对肿瘤靶区进行勾画时,需充分对其影响进行考虑。

Objective:To investigate the effect of respiratory movement on tumor target volume in patients with lung cancer undergoing three-dimensional conformal radiotherapy.Methods:30 cases of primary non small cell lung cancer patients were admitted to our hospital from February 2016 to February 2017,three-dimensional conformal radiotherapy was performed,and the influence of respiratory movements on tumor target volume and location were analyzed by Eclipse 13.6 treatment plan system.Results:The volume of tumor target area under fusion image and quiet breathing state,the volume under fusion image and diagnostic image,and the volume under quiet breathing state and diagnostic image were compared,and there were statistical differences among lesions in different parts(P<0.05).Conclusion:The application of three-dimensional conformal radiotherapy in patients with lung cancer treatment,respiratory movement can cause the change of tumor target volume,accompanied by central coordinate shift,and its influence should be fully considered when the tumor target area is delineated.