铁死亡纳米探针在肿瘤治疗中应用的研究进展

Research progress of iron death nanoprobe in tumor therapy

铁死亡是新发现的一种异于凋亡形式的细胞死亡形式,是一种新型的铁依赖型程序性细胞死亡的过程。铁死亡与脂质过氧化和铁离子代谢密切相关。近年来已经开发出许多纳米探针结合铁死亡疗法来进行肿瘤治疗。其构建的主要思路是通过增强肿瘤细胞内芬顿反应与消耗谷胱甘肽(glutathione,GSH)或者使谷胱甘肽过氧化物酶4(glutathione peroxidase 4,GPX4)失活导致氧化损伤两种途径。本文将对使用铁死亡纳米探针在肿瘤治疗中的最新研究进展及应用进行综述。

Iron death is a newly discovered form of cell death different from apoptosis,and is a new iron-dependent programmed cell death process.Iron death is closely related to lipid peroxidation and iron metabolism.In recent years,many nanoprobes combined with iron death therapy have been developed for tumor therapy.The main idea of its construction is to enhance fenton response in tumor cells,consume glutathione(GSH)or inactivate glutathione peroxidase 4(GPX4)to lead to oxidative damage.This review will review the recent research progress and application of iron death nanoprobes in tumor therapy.