血清前列腺特异性抗原、前列腺特异性抗原密度和可溶性上皮钙黏蛋白水平检测对前列腺癌的诊断价值

Diagnostic value of serum prostate specific antigen,prostate specific antigen density,soluble epithelial cadherin levels in prostate cancer

目的探讨血清前列腺特异性抗原(PSA)、前列腺特异性抗原密度(PSAD)和可溶性上皮钙黏蛋白(sE-cad)水平检测对前列腺癌的诊断价值。方法选取2020年4月至2021年4月监利市中医医院收治的300例前列腺癌患者作为研究组,另选取监利市中医医院同期280例男性体检健康者作为对照组。比较两组研究对象血清PSA、PSAD、sE-cad水平,采用受试者工作特征(ROC)曲线分析血清PSA、PSAD、sE-cad单独诊断与联合检测的敏感度、特异度、阳性预测值、阴性预测值及准确度。结果研究组的血清PSA、PSAD、sE-cad水平高于对照组,差异有统计学意义(P<0.05)。PSA诊断前列腺癌的敏感度、特异度、准确度分别为80.00%、90.00%、84.43%,PSAD诊断前列腺癌的敏感度、特异度、准确度分别为83.33%、92.86%、87.93%,sE-cad诊断前列腺癌的敏感度、特异度、准确度分别为66.67%、71.42%、68.97%,联合检测的敏感度、特异度、准确度分别为96.67%、98.21%、97.41%,联合检测的诊断价值高于单项检测,差异有统计学意义(P<0.05)。ROC曲线结果显示,血清PSA、PSAD、sE-cad单独及联合检测前列腺癌的曲线下面积分别为86.2、87.6、68.2、96.8,95%CI分别为0.829~0.894、0.845~0.907、0.638~0.727、0.957~0.980,血清PSA、PSAD、sE-cad联合检查的诊断效能均高于单项检查,差异有统计学意义(P<0.05)。结论前列腺癌患者血清PSA、PSAD、sE-cad水平显著升高,联合检测前列腺癌的诊断价值较高,值得临床推广应用。

Objective To investigate the serum prostate-specific antigen(PSA),prostate specific antigen density(PSAD)and soluble epithelial cadherin(sE-cad)in the diagnosis of prostate cancer.Methods A total of 300 prostate cancer patients admitted to Jianli Hospital of Traditional Chinese Medicine from April 2020 to April 2021 were selected as the research group,and 280 healthy male from Jianli Hospital of Traditional Chinese Medicine during the same period were selected as the control group.Serum Levels of PSA,PSAD and sE-cad were compared between the two groups.The sensitivity,specificity,positive predictive value,negative predictive value and accuracy of serum PSA,PSAD and sE-cad single and combined detection were analyzed by receiver operating characteristic(ROC)curve.Results The levels of serum PSA,PSAD and sE-cad in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The sensitivity,specificity and accuracy of PSA in the diagnosis of prostate cancer were 80.00%,90.00%and 84.43%.The sensitivity,specificity and accuracy of PSAD in the diagnosis of prostate cancer were 83.33%,92.86%and 87.93%.The sensitivity,specificity and accuracy of sE-cad were 66.67%,71.42%and 68.97%.The sensitivity,specificity and accuracy of combined detection were 96.67%,98.21%and 97.41%.The diagnostic value of combined detection was higher than that of single detection,and the difference was statistically significant(P<0.05).ROC curve results showed that the areas under curve of serum PSA,PSAD and sE-cad single and combined detection were 86.2,87.6,68.2 and 96.8 respectively,95%CI were 0.829-0.894,0.845-0.907,0.638-0.727 and 0.957-0.980,respectively.The diagnostic efficacy of serum PSA,PSAD and sE-cad combined detection was higher than that of single detection,and the difference was statistically significant(P<0.05).Conclusion The levels of serum PSA,PSAD and sE-cad in patients with prostate cancer are significantly increased.The combined detection of prostate cancer has high diagnostic value and is worthy of clinical application.