丹参地黄止痛方联合常规西药治疗老年骨质疏松症临床研究

Clinical Study on Salvia and Rehmannia for Relieving Pain Formula Combined with Conventional Western Medicine in the Treatment of Senile Osteoporosis

目的:观察自拟丹参地黄止痛方联合常规西药治疗老年骨质疏松症的临床疗效。方法:将70例老年骨质疏松症患者按照随机数字表法分为对照组和观察组,每组各35例。对照组给予常规西药治疗,观察组在对照组治疗的基础上给予自拟丹参地黄止痛方治疗。比较两组患者的临床疗效及治疗前后中医证候积分、骨密度水平、视觉模拟评分法(visual analogue score,VAS)评分、Oswestry功能障碍指数(Oswestry disability index,ODI)评分、日常生活自理能力(activity of daily living,ADL)评分变化情况。结果:观察组有效率为94.29%,对照组有效率为77.14%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组治疗后中医证候积分低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。两组治疗后骨密度水平高于本组治疗前,且治疗后观察组高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后VAS评分、ODI评分均低于本组治疗前,ADL评分均高于本组治疗前,且治疗后观察组VAS评分、ODI评分均低于对照组,ADL评分高于对照组,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:自拟丹参地黄止痛方联合常规西药治疗老年骨质疏松症,能明显改善患者骨密度,缓解疼痛,提高生活质量。

Objective:To observe the clinical efficacy of self-made Salvia and Rehmannia for Relieving Pain Formula combined with conventional Western medicine on senile osteoporosis.Methods:A total of 70 patients with senile osteoporosis were randomly divided into the control group and the observation group,with 35 cases in each group.The control group was treated with conventional Western medicine,while the observation group was treated with self-made Salvia and Rehmannia for Relieving Pain Formula on the basis of the treatment of the control group.The clinical efficacy and changes of TCM syndrome score,bone mineral density test results,visual analog score(VAS),Oswestry disability index(ODI) score and activity of daily living(ADL) score before and after treatment were compared between the two groups.Results:The effective rate was 94.29% in the observation group and 77.14% in the control group.There was significant difference between the two groups(P<0.05).The TCM syndrome score of the two groups after treatment was lower than that before treatment,and the index of the observation group after treatment was lower than that of the control group,and the difference was statistically significant(P<0.05).The bone mineral density test results of the two groups after treatment were higher than that of the same group before treatment,and the index of the observation group after treatment was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the VAS score and ODI score of the two groups were lower than those of the same group before treatment,and the ADL score was higher than that of the same group before treatment;The VAS score and ODI score of the observation group were lower than those of the control group,and the ADL score was higher than that of the control group.And all the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Self-made Salvia and Rehmannia for Relieving Pain Formula combined with conventional Western medicine can significantly improve the bone mineral density,relieve pain and improve the quality of life of patients with senile osteoporosis.