基于HRCT探讨血清维生素A、ANCA、TIMP-1水平在支气管炎患儿病情及预后评估中的价值

Discussion on the value of serum vitamin A,ANCA and TIMP-1 levels in the evaluation of the condition and prognosis of children with bronchitis based on HRCT

目的:分析基于HRCT探讨血清维生素A、ANCA、TIMP-1水平在支气管炎患儿病情及预后评估中的价值。方法:将我院2019年12月至2021年1月间收治的132例支气管炎患者依照临床HRCT扫描将患者分为轻度组、中度组和重度组;采用酶联免疫吸附法检测受试者血中维生素A、ANCA、TIMP-1水平;采用spearman相关性检验分析维生素A、ANCA、TIMP-1与患者病情严重程度的相关性,绘制ROC曲线分析各指标单独和联合应用预测支气管炎价值。结果:轻度组、中度组和重度组患者血中维生素A、ANCA、TIMP-1水平存明显差异,其中轻度组患者维生素A水平最高,ANCA和TIMP-1水平最低,且组间差异存在统计学意义(P<0.05);痊愈+显效亚组患者维生素A水平明显高于进展+无效亚组,ANCA和TIMP-1水平明显低于进展+无效亚组,且差异存在统计学意义(P<0.05);支气管肺炎患者血中维生素A与患者病情严重程度呈显著负相关关系,ANCA和TIMP-1水平与患者病情严重程度呈显著正相关关系,且差异存在统计学意义(P<0.05);维生素A、ANCA、TIMP-1水平联合应用预测患者治疗质量的敏感度、特异度及AUC均明显高于各指标单独应用,且差异存在统计学意义(P<0.05)。结论:维生素A与基于HRCT患者病情严重程度呈显著负相关关系,ANCA、TIMP-1水平呈显著正相关关系,且维生素A、ANCA、TIMP-1联合应用预测患者治疗临床疗效的敏感度、特异度、AUC均显著高于各指标单独应用。

132 patients with bronchitis in our hospital from December 2019 to January 2021 were divided into mild group,moderate group and severe group according to clinical HRCT scan.The levels of vitamin A,ANCA and TIMP-1 were detected by enzyme-linked immunosorbent assay.Spearman correlation test was used to analyze the correlation between vitamin A,ANCA,TIMP-1 and the severity of the disease.ROC curve was drawn to analyze the value of each index in predicting bronchitis.There were significant differences in the levels of vitamin A,ANCA and TIMP-1 among mild group,moderate group and severe group.The levels of vitamin A in the mild group(P<0.05)were the highest,while the levels of ANCA and TIMP-1 were the lowest,and the differences were statistically significant.The levels of vitamin A,ANCA and TIMP-1 in the cured+markedly effective subgroup were significantly higher than those in the progressive+ineffective subgroup,and the differences were statistically significant(P<0.05).The levels of ANCA and TIMP-1 were positively correlated with the severity of the disease,and the difference was statistically significant(P<0.05).The sensitivity,specificity and AUC of the combined application of vitamin A,ANCA and TIMP-1 in predicting the quality of treatment were significantly higher than those of the single application of each index,and the difference was statistically significant(P<0.05).It can be seen that there is a significant negative correlation between vitamin A and the severity of HRCT patients,and a significant positive correlation between the levels of ANCA and TIMP-1.The sensitivity,specificity and AUC of the combined application of vitamin A,ANCA and TIMP-1 in predicting the clinical efficacy of HRCT patients are significantly higher than those of each index alone.