肥胖儿童血糖、血脂代谢特征与性早熟的相关性分析

Correlation of Blood Glucose and Lipid Metabolism Characteristics with Precocious Puberty in Obese Children

目的:分析肥胖儿童的血糖与血脂代谢特征与性早熟的相关性。方法:选取2019年9月-2021年6月在北京京煤集团总医院儿科就诊的肥胖儿童60例为观察组,其中42例儿童肥胖,18例儿童合并性早熟,另选取同期60例健康儿童作为对照组,检测两组儿童血糖和血脂代谢指标,分析肥胖患儿血糖和血脂代谢特征及其与儿童性早熟之间的相关性。结果:对照组空腹血糖、糖化血红蛋白和餐后2 h血糖高于观察组,差异具有统计学意义(P<0.05);观察组的甘油三酯、低密度脂蛋白胆固醇和血清总胆固醇均高于对照组,观察组高密度脂蛋白胆固醇、尿素氮低于对照组,差异具有统计学意义(P<0.05);合并性早熟儿童的男童阴毛Tanner评分、睾丸Tanner评分和女童阴毛Tanner评分、女童乳房Tanner评分均明显高于单纯肥胖儿童,差异具有统计学意义(P<0.05);性早熟与肥胖儿童的空腹血糖、糖化血红蛋白、餐后2 h血糖、甘油三酯、低密度脂蛋白胆固醇和血清总胆固醇呈现出正相关,与高密度脂蛋白胆固醇和尿素氮呈现出负相关,差异具有统计学意义(P<0.05)。结论:肥胖儿童的血脂与血糖指标和性早熟发生之间具有相关性,临床应尽早对肥胖儿童做好筛查工作,同时采取健康指导,预防性早熟发生,促使儿童健康成长和发育。

Objective:To analyze the correlation of the characteristics of blood glucose and lipid metabolism with precocious puberty in obese children.Methods:A total of 60 obese children who visited the Department of Pediatrics,Beijing Jingmei Group General Hospital from September 2019 to June 2021 were selected as the observation group,including 42 obese children and 18obese children combined with precocious puberty.Another 60 healthy children during the same period were selected as the control group.The blood glucose and blood lipid metabolism indexes of children of the two groups were examined,and the characteristics of blood glucose and blood lipid metabolism in obese children and their correlation with precocious puberty were analyzed.Results:The fasting blood glucose,glycosylated hemoglobin and 2 h postprandial blood glucose in the control group were higher than those in the observation group,and the difference was statistically significant(P<0.05).The triglyceride,low-density lipoprotein cholesterol and serum total cholesterol in the observation group were higher than those in the control group,and the highdensity lipoprotein cholesterol and blood urea nitrogen in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The triglyceride,low-density lipoprotein cholesterol and serum total cholesterol in the observation group were higher than those in the control group,and the high-density lipoprotein cholesterol and blood urea nitrogen in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The boy pubic hair Tanner score,testis Tanner score,girl pubic hair Tanner score and girl breast Tanner score of children with precocious puberty were significantly higher than those of simple obesity children,and the difference was statistically significant(P<0.05).Precocious puberty was positively correlated with fasting blood glucose,glycated hemoglobin,2 h postprandial blood glucose,triglyceride,low-density lipoprotein cholesterol,and serum total cholesterol in obese children,and negatively correlated with high-density lipoprotein cholesterol and blood urea nitrogen,with statistically significant difference(P<0.05).Conclusion:There is a correlation of blood lipid indexes and blood glucose indexes with the occurrence of precocious puberty in obese children.Clinical screening of obese children should be done as soon as possible.At the same time,health guidance should be taken to prevent the occurrence of precocious puberty and promote the healthy growth and development of children.