摘要
随着大规模根除治疗的推进,导致幽门螺杆菌(H.pylori)耐药率不断升高,加上宿主CYP2C19基因多态性、H.pylori球形变、患者依从性、医生治疗方案不正规或经验式反复根除治疗等因素,H.pylori根除率逐渐下降。个性化治疗是实现H.pylori感染者首诊成功得以根除的有效措施。随着克拉霉素耐药分子诊断试剂盒在我国首次获批与美国胃肠病协会(AGA)有关难治性H.pylori感染定义更新,遵循国际最新共识与指南、符合国情、赶超国际水平的基于耐药基因检测的H.pylori首诊个性化诊疗走向前台。
As widespread eradication treatment continues,the rate of(Helicobacter pylori,H.pylori)antibiotic resistance is increasing.Together with host CYP2C19 gene polymorphisms,H.pylori coccoid transformation,patient compliance,irregular treatment regimens or empirical repeated eradication therapy by physician,H.pylori eradication rates have gradually decreased.Personalized treatment is an effective measure to achieve successful eradication of H.pylori in the initial treatment.With the first approval of molecular diagnostic kit for H.pylori clarithromycin resistance in China and the updated definition of refractory H.pylori infection by the American Gastroenterological Association(AGA),the personalized treatment of H.pylori guided by antibiotic resistance genotype detection in initial treatment,that follows the latest international consensus and guidelines,conforms to the national situation and surpasses the international standards,has come to the forefront.
作者
郜恒骏
钟子劭
闫利娟
张小燕
沈维祥
Gao Hengjun;Zhong Zishao;Yan Lijuan;Zhang Xiaoyan;Shen Weixiang(Tongji Hospital,Institute of Digestive Diseases,School of Medicine,Tongji University,Shanghai 200065,China;China Center for Helicobacter pylori Molecular Medicine,Shanghai 201321,China;National Engineering Center for Biochips at Shanghai,Shanghai 201203,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2022年第22期1631-1634,共4页
National Medical Journal of China
基金
上海市科学技术委员会科研计划项目(19441911200)
上海市浦东新区科技发展基金(PKX2021-S08)
中国博士后科学基金(2020M670068ZX)。
关键词
幽门螺杆菌
个性化治疗
细菌
耐药
Helicobacter pylori
Personalized treatment
Bacteria
Antibiotic resistance