选择性剪接在口腔鳞状细胞癌中的研究进展

Research Progress of Alternative Splicing in Oral Squamous Cell Carcinoma

选择性剪接是转录后基因表达调控的关键步骤,它的异常与肿瘤发生密切相关。本文系统阐述了口腔鳞状细胞癌中选择性剪接的调控、具体事件及预后模型的开发,为探索口腔鳞状细胞癌靶向治疗提供新的思路。

Alternative splicing is a key step in the regulation of post-transcriptional gene expression,and its dysfunction is closely related to tumorgenesis.This review systematically describes the regulation,specific events and development of prognostic model of alternative splicing in oral squamous cell carcinoma,to provide a new idea for the exploration of targeted therapy on oral squamous cell carcinoma.