肺曲菌球的非手术局部治疗研究进展

Non-surgical local treatment for pulmonary aspergilloma

肺曲菌球通常继发于肺内空腔中,治疗目的主要是预防威胁生命的大咯血。手术切除被认为是首选治疗方案,但许多患者无法耐受手术。因肺曲菌球通常不侵及肺空腔周围血管,口服或静脉注射抗真菌治疗效果较差。此时可考虑动脉栓塞、局部注入药物、放射治疗等方法。本文将对肺曲菌球(咯血)的各种非手术局部治疗进行概括和总结,为临床决策提供参考。

Pulmonary aspergilloma(PA)is usually secondary to pulmonary cavities.The main purpose of PA treatment is to prevent life-threatening hemoptysis.Many patients cannot tolerate surgical resection,which is considered the preferred treatment.Oral or intravenous antifungal therapy is less effective because PA usually does not invade the blood vessels of the pulmonary cavity.In this case,arterial embolization,local injection with drugs,and radiation therapy can be considered.This article will summarized various non-surgical local treatments for PA(hemoptysis)to refer clinical decision-making.