铁死亡脂质过氧化机制及其与阿尔茨海默病的联系

Lipid peroxidation in ferroptosis and its relationship with Alzheimer disease

阿尔茨海默病(Alzheimer disease,AD)是多发于65岁及以上老年人群的中枢神经系统退行性疾病,临床表现以记忆、语言及其他认知能力衰退为主,主要病理特征为以β-淀粉样蛋白(amyloidβ-protein,Aβ)为核心成分的老年斑及tau蛋白过度磷酸化引起的神经原纤维缠结。在日益增强的老龄化趋势下.

Lipid peroxidation is one of the commonest pathological processes of Alzheimer disease(AD)and a key player in a novel form of regulated cell death named ferroptosis. The products of lipid peroxidation are considered as executors of ferroptosis. Recent studies reveal that signature proteins of ferroptosis and products of lipid peroxidation accumulate in AD brains. Peroxidation process also involves amyloid β-protein deposition and pathological hyperphosphorylation of tau protein. Therefore,lipid peroxidation mechanism of ferroptosis might play a role in AD progression. This review summarizes the recent progress in lipid peroxidation mechanism and its regulated axis of ferroptosis,collating evidences of the relationship between lipid peroxidation and characteristic pathological processes of AD.