埃索美拉唑与奥美拉唑治疗胃溃疡的临床效果分析

Clinical effect analysis of esomeprazole and omeprazole in treatment of gastric ulcer

目的分析胃溃疡疾病特点,评价应用埃索美拉唑与奥美拉唑治疗的效果,为临床提供参考。方法选取2018年1月至2021年1月福建省建新医院收治的80例胃溃疡患者为研究对象,按照随机数字表法分为常规组和研究组,各40例。常规组患者采用奥美拉唑治疗,研究组患者采用埃索美拉唑治疗,比较两组患者的治疗效果及不良反应发生情况;分析两组患者治疗后的表皮生长因子(EGF)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平;比较两组患者住院时间、临床症状消失时间。结果研究组患者的治疗有效率为97.50%,显著高于常规组的75.00%(P<0.05);研究组患者不良反应发生率为2.50%,显著低于常规组的15.00%(P<0.05);研究组患者治疗后的EGF水平显著高于常规组,而TNF-α、IL-6水平显著低于常规组(P<0.05);研究组患者住院时间、临床症状消失时间显著短于常规组(P<0.05)。结论采用埃索美拉唑治疗胃溃疡的效果明显优于奥美拉唑,不仅能够明显改善患者的临床症状,还能降低患者不良反应发生率,值得临床应用。

Objective To analyze the characteristics of gastric ulcer disease and evaluate the efficacy of esomeprazole and omeprazole in the treatment of gastric ulcer disease,so as to provide clinical reference.Methods 80 patients with gastric ulcer treated in Jianxin Hospital of Fujian province from January 2018 to January 2021 were selected for retrospective analysis,and were randomly divided into routine group and study group,with 40 patients in each group.Patients in the routine group were treated with omeprazole and patients in the study group were treated with esomeprazole.The therapeutic effects and adverse reactions of the two groups were compared;The epidermal growth factor(EGF)and tumor necrosis factor-α(TNF-α)、interleukin-6(IL-6)level after treatment were analyzed.The hospitalization time and the disappearance time of clinical symptoms were analyzed and compared between the two groups.Results The treatment effective rate of patients in the study group was 97.50%,which was significantly higher than 75.00% in the routine group(P<0.05).The probability of adverse reactions in the study group was 2.50%,which was significantly lower than that in the routine group.The probability of adverse reactions in the study group was significantly lower than that in the routine group(P<0.05).The increase of EGF in the study group was significantly higher than that in the routine group,while TNF-α、IL-6 was significantly lower than that in routine group(P<0.05).The hospitalization time and the disappearance time of clinical symptoms in the study group were significantly shorter than those in the routine group(P<0.05).Conclusion The effect of esomeprazole in the treatment of gastric ulcer is more obvious than that of omeprazole.It can not only significantly improve the clinical symptoms of patients,alleviate them and recover them as soon as possible,but also reduce the probability of adverse reactions.It is worthy of wide application in clinic.