丙戊酸镁缓释片和帕罗西汀联合拉莫三嗪治疗双相抑郁患者的效果分析

Effect Analysis of Magnesium Valproate Sustained-release Tablets and Paroxetine Combined with Lamotrigine in the Treatment of Patients with Bipolar Depression

目的:分析丙戊酸镁缓释片和帕罗西汀联合拉莫三嗪治疗双相抑郁患者的效果。方法:选择2019年12月—2021年12月该院收治的122例双相抑郁患者作为研究对象,通过随机数字表法分为对照组和试验组,每组61例。对照组口服丙戊酸镁缓释片和帕罗西汀治疗,试验组在对照组基础上加用拉莫三嗪治疗,比较两组临床疗效、抑郁状况、心理弹性及不良反应发生情况。结果:试验组总有效率为96.72%,高于对照组的80.33%(P<0.05);试验组迟滞、绝望感、日夜变化、体重变化、认知障碍、睡眠障碍、焦虑/躯体化评分及HAMD总分低于对照组(P<0.05);试验组乐观性、力量性、坚韧性评分及CD-RISC总分高于对照组(P<0.05);对照组和试验组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:双相抑郁患者应用丙戊酸镁缓释片和帕罗西汀联合拉莫三嗪治疗效果显著,可明显改善患者抑郁状况、心理弹性,且安全性较高。

Objective: To analyze the effect of magnesium valproate sustained-release tablets and paroxetine combined with lamotrigine in the treatment of patients with bipolar depression. Methods: A total of 122 patients with bipolar depression admitted to our hospital from December 2019 to December 2021 were selected and randomly divided into control group and experimental group, with 61 cases in each group. The control group was treated with magnesium valproate sustained-release tablets and paroxetine, and the experimental group was treated with lamotrigine on the basis of the control group. The clinical efficacy, depression, resilience and adverse reactions were compared between the two groups. Results: The total effective rate of the experimental group was 96.72%, which was higher than 80.33% of the control group(P<0.05);The scores of hysteresis, despair, day and night changes, weight change, cognitive impairment, sleep disorders, anxiety/somatization and HAMD total score in the experimental group were lower than those in the control group(P<0.05);The scores of optimism,strength, toughness and CD-RISC in the experimental group were higher than those in the control group(P<0.05);There was no significant difference in the incidence of adverse reactions between the control group and the experimental group(P>0.05).Conclusion: The application of magnesium valproate sustained-release tablets and paroxetine combined with lamotrigine in the treatment of patients with bipolar depression is effective, which can significantly improve the patients’ depression and psychological resilience, and has high safety.