奥拉帕利片治疗结直肠癌根治术患者的疗效及对TSLPR、MAPs、Cx43表达的影响

Effect of Orapalide Tablets on Expression of TSLPR,MAPs and Cx43 in Patients Undergoing Radical Resection of Colorectal Cancer

目的:研究探讨奥拉帕利片对结直肠癌根治术患者术后的疗效及对胸腺基质淋巴细胞生成素受体(TSLPR)、微管相关蛋白(MAPs)、缝隙连接蛋白43(Cx43)表达的影响。方法:选取2019年1月—2021年10月本院收治的110例结直肠癌患者为研究对象,随机分为观察组和对照组,每组55例。所有患者均进行结直肠癌根治术治疗,对照组术后予以伊立替康^(+)亚叶酸钙^(+)氟尿嘧啶(FOLFIRI)方案治疗,观察组在对照组基础上联合奥拉帕利片治疗,比较两组临床疗效、肿瘤标志物水平、免疫功能指标、炎症损伤指标、治疗安全性等。结果:观察组客观缓解率(ORR)为70.91%、疾病控制率(DCR)为85.45%,高于对照组的50.91%、69.09%(P<0.05)。观察组CA19-9、CA242、CEA均低于对照组(P<0.05);观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组(P<0.05);观察组TSLPR、MAPs、Cx43水平均低于对照组(P<0.05);观察组与对照组不良反应发生率分别为18.18%、12.73%,组间比较,差异无统计学意义(P>0.05)。结论:奥拉帕利片在结直肠癌术后患者中的应用效果良好,能够降低肿瘤标志物水平,改善患者免疫功能,抑制炎症相关蛋白的表达,治疗安全性良好。

Objective:To investigate the efficacy of orapalide tablets on postoperative patients with colorectal cancer undergoing radical resection and its effect on the expression of thymic stromal lymphocyte receptor(TSLPR),microtubule associated proteins(MAPs)and gap junction protein 43(Cx43).Methods:A total of 110 patients with colorectal cancer admitted to our hospital from January 2019 to October 2021 were randomly divided into observation group and control group,with 55 cases in each group.All patients were treated with radical resection of colorectal cancer.The control group was treated with irinotecan^(+)calcium folinate^(+)fluorouracil(FOLFIRI)regimen after operation,and the observation group was treated with Olapari tablets on the basis of the control group.The clinical efficacy,tumor marker level,immune function index,inflammatory injury index and treatment safety of the two groups were compared.Results:The objective remission rate(ORR)and disease control rate(DCR)of the observation group were 70.91%and 85.45%,respectively,which were higher than those 50.91%and 69.09%of the control group(P<0.05).The tumor markers of CA19-9,CA242 and CEA in the observation group were lower than those in the control group(P<0.05).CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and CD8^(+)was lower than that in the control group(P<0.05).The levels of TSLPR,MAPs and Cx43 in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group and the control group was 18.18%and 12.73%,respectively,there was no significant difference between the two groups(P>0.05).Conclusion:The application effect of Olapari tablets in patients with colorectal cancer after operation is good,which can reduce the level of tumor markers,improve the immune function,and inhibit the expression of inflammatory related proteins,and with higher treatment safety.