胎盘多肽注射液联合紫杉醇、顺铂对晚期卵巢癌血清CA125、HE4水平的影响

Effect of Placental Polypeptide Injection Combined with Paclitaxel and Cisplatin on Serum CA125 and HE4 Levels in Advanced Ovarian Cancer

目的:研究胎盘多肽注射液联合紫杉醇、顺铂对晚期卵巢癌血清糖类抗原125(CA125)和人附睾分泌蛋白4(HE4)水平的影响。方法:选择2014年1月—2019年1月我院收治的90例晚期卵巢癌患者,随机分为对照组和观察组,每组45例。对照组采取紫杉醇、顺铂化疗,观察组在对照组基础上联用胎盘多肽注射液治疗,比较两组临床疗效、免疫功能、生活质量、血清CA125及HE4水平、不良反应发生率。结果:观察组治疗总有疗效高于对照组(P<0.05);观察组治疗后CD4^(+)、CD3^(+)、CD4^(+)/CD8^(+)及Karnofsky评分高于对照组(P<0.05);观察组治疗后血清CA125及HE4水平低于对照组(P<0.05);观察组不良反应发生率低于对照组(P<0.05)。结论:胎盘多肽注射液联合紫杉醇、顺铂能提高晚期卵巢癌患者的免疫功能,改善生活质量,降低血清CA125、HE4水平,减少化疗药物不良反应。

Objective: To study the effect of placental polypeptide injection combined with paclitaxel and cisplatin on serum carbohydrate antigen 125(CA125) and human epididymal secretory protein 4(HE4) levels in advanced ovarian cancer.Methods: A total of 90 patients with advanced ovarian cancer admitted to our hospital from January 2014 to January 2019were randomly divided into control group and observation group, with 45 cases in each group. The control group was treated with paclitaxel and cisplatin chemotherapy, and the observation group was treated with placenta polypeptide injection on the basis of the control group. The clinical efficacy, immune function, quality of life, serum CA125 and HE4 levels and incidence of adverse reactions were compared between the two groups. Results: The total curative effect of the observation group was higher than that of the control group(P<0.05). After treatment, the scores of CD4^(+), CD3^(+), CD4^(+)/CD8^(+) and Karnofsky in the observation group were higher than those in the control group(P<0.05). Serum CA125 and HE4 levels in the observation group were lower than those in the control group after treatment(P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).. Conclusion: Placenta polypeptide injection combined with paclitaxel and cisplatin can improve the immune function of patients with advanced ovarian cancer, improve the quality of life, reduce the levels of serum CA125 and HE4, and reduce the adverse reactions of chemotherapy drugs.