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血清血红素加氧酶-1同型半胱氨酸水平与急性心肌梗死患者冠状动脉病变程度的关系

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摘要 目的观察血清血红素加氧酶-1(HO-1)、同型半胱氨酸(Hcy)在急性心肌梗死(AMI)患者中的表达,并分析二者与冠状动脉病变程度的关系。方法选择2019年1月至2021年4月洛阳市中医院接收的93例AMI患者为研究对象,患者入院时采用Gensini评分法评估冠状动脉病变程度并分组,分为轻度、中度及重度组,调查并比较3组基线资料及入院时血清HO-1、Hcy水平,分析血清HO-1、Hcy水平与AMI患者冠状动脉病变程度的关系。结果全部93例患者中,轻度病变26例,中度病变39例,重度病变28例;重度组入院时血清HO-1水平低于中、轻度组,Hcy水平高于中、轻度组(P<0.05);中度组入院时血清HO-1水平低于轻度组,Hcy水平高于轻度组,差异有统计学意义(P<0.05);经双变量Kendall的tau-b(K)直线相关性分析结果显示,AMI患者冠状动脉病变程度与血清HO-1水平呈负相关(r=-0.601,P<0.05),与血清Hcy水平呈正相关(r=0.732,P<0.05)。结论血清HO-1水平与AMI患者冠状动脉病变程度呈负相关,血清Hcy水平与AMI患者冠状动脉病变程度呈正相关。
作者 肖利辉
出处 《实用医技杂志》 2022年第6期644-646,共3页 Journal of Practical Medical Techniques
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