小儿支原体肺炎血清白介素-6水平与心肌损害的相关性分析

Correlation between Serum Interleukin-6 Level and Myocardial Damage in Paediatric Mycoplasma Pneumonia

目的:分析小儿支原体肺炎(MPP)血清白介素-6(IL-6)水平与心肌损害(MD)的相关性。方法:选取2019年6月到2021年6月于我院收治的138例小儿MPP为研究对象,根据疾病进程分为MD组与无MD组,比较两组的性别、年龄、血白细胞(WBC)、降钙素原(PCT)、C反应蛋白(CRP)、心肌型肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)、IL-6水平及住院时间。采用受试者工作特征(ROC)曲线的曲线下面积(AUC)评价各指标对MD发生的诊断价值,采用Pearson相关性分析全部患儿的血清IL-6水平与住院时间的关系。结果:全部138例患儿共发现有33例出现MD,发生率为23.9%。MD组患儿的血清CRP、PCT、CK-MB、cTnI、IL-6水平、住院时间显著高于无MD组,差异有统计学意义(P<0.05)。两组患儿的性别、年龄、血WBC水平比较,差异无统计学意义(P>0.05)。ROC曲线结果表明IL-6、CK-MB、cTnI对MD的诊断价值较高(AUC>0.9),CRP、PCT具有一定的诊断价值(AUC为0.7~0.9),而年龄与WBC未见明显的诊断价值(AUC<0.7)。Pearson相关性分析表明全部患儿的血清IL-6水平与住院天数呈正相关(r=0.328,P=0.001<0.05)。结论:MPP患儿的血清IL-6水平对MD的发生有潜在的诊断价值,且与住院天数有关,值得临床参考应用。

Objective:To analyze the correlation between serum Interleukin-6(IL-6)level and myocardial damage(MD)in paediatric mycoplasma pneumonia(MPP).Methods:One hundred and thirty-eight children with MPP treated in our hospital from June 2019 to June 2021 were enrolled for the research and divided into MD group and non-MD group according to the disease process.The gender,age,blood leukocyte(WBC),procalcitonin(PCT),C-reactive protein(CRP),creatine kinase-MB isoenzyme(CK-MB),cardiac troponin I(cTnI),IL-6 levels and hospitalization time were compared between the two groups.The area under the curve(AUC)of receiver operating characteristic(ROC)curve was performed to evaluate the diagnostic value of these indexes for MD.Pearson correlation was used to analyze the relationship between serum IL-6 level and hospitalization time.Results:Myocardial damage occurred in 33 of 138 children,with an incidence of 23.9%.The serum levels of CRP,PCT,CK-MB,cTnI,IL-6 and hospitalization time in MD group were significantly higher than those in non-MD group(P<0.05).There were no significant differences in gender,age and WBC between two groups(P>0.05).The results of ROC curve showed that IL-6,CK-MB and cTnI had high diagnostic value for myocardial damage(AUC>0.9)while CRP and PCT had certain diagnostic value(AUC 0.7~0.9),but age and WBC had no obvious diagnostic value(AUC<0.7).Pearson correlation analysis showed that the serum IL-6 level of all children was significantly positively correlated with the length of hospital stay(r=0.328,P=0.001<0.05).Conclusion:Serum level of IL-6 has a potential diagnostic value for the occurrence of myocardial damage in children with MPP,and it is related to the length of hospital stay,which is worthy of clinical reference.