地西泮对高热惊厥复发患儿热退发热和惊厥复发免疫球蛋白水平和血清NSE水平的影响

Effects of Diazepam on Fever Regression Rever and Convulsion Recurrence Immunoglobulin Level and Serum NSE Level in Children with Recurrent Febrile Convulsion

目的:分析地西泮对高热惊厥复发患儿热退、发热和惊厥复发、免疫球蛋白水平和血清NSE水平的影响。方法:选取本院2019年1月至2021年1月收治的200例惊厥患儿,简单随机分组分为对照组(给予一般治疗)和试验组(给予地西泮+一般治疗),两组各100例。记录两组高热惊厥复发患儿热退、发热和惊厥复发、免疫球蛋白水平和血清NSE水平情况。结果:经重复测量数据方差分析,结果显示两组患者体温在不同组间、时间及组间与时间交互作用上差异有统计学意义(P<0.05)。试验组患儿与对照组患儿相比,治疗前1d及治疗后3周IgG水平及IgA水平均无明显不同(P>0.05)。两组患儿治疗前1d及治疗后3周IgG水平及IgA水平比较,均无明显不同(P>0.05)。两组患儿治疗前血清NSE含量比较,均无明显不同(P>0.05)。两组治疗后3周血清NSE含量均低于治疗前,且试验组治疗后血清NSE含量均低于对照组(P<0.05)。对照组出现发热复发10例,惊厥复发7例;试验组出现发热复发2例,惊厥复发0例。两组患儿发热复发及惊厥复发发生率比较,差异有统计学意义(χ^(2)=5.674,7.254;P<0.05)。结论:地西泮可提升高热惊厥复发患儿的临床疗效,减轻临床症状,该疗法具有较高的有效性和安全性,对免疫功能无明显改善。

Objective:To analyze the effects of diazepam on fever regression,fever and convulsion recurrence,immunoglobulin level and serum NSE level in children with recurrent febrile convulsion.Methods:A total of 200 children with convulsion admitted to our hospital from January 2019 to January 2021 were randomly divided into control group(given general treatment)and experimental group(given diazepam+general treatment),with 100 cases in each group.The fever regression,fever and convulsion recurrence,immunoglobulin level and serum NSE level of children with recurrent febrile convulsion in the two groups were recorded.Results:Analysis of variance(ANOVA)on repeated measurements showed statistically significant differences in body temperature between the 2 groups,in time and in the interaction between groups and time(P<0.05).There was no significant difference in IgG levels and IgA levels between the 2 groups 1 d before and 3 weeks after treatment compared to the control group(P>0.05).There was no significant difference in IgG levels and IgA levels between the 2 groups 1 d before and 3 weeks after treatment(P>0.05).There was no significant difference in serum NSE levels between the 2 groups before treatment(P>0.05).The serum NSE level was lower in both groups 3 weeks after treatment than before treatment,and the serum NSE level was lower in the test group than in the control group after treatment(P<0.05).In the control group,there were 10 cases of fever recurrence and 7 cases of convulsion recurrence;in the test group,there were 2 cases of fever recurrence and 0 cases of convulsion recurrence.The difference in the incidence of fever recurrence and convulsion recurrence between the 2 groups was statistically significant(χ^(2)=5.674,7.254;P<0.05).Conclusion:Diazepam improves clinical outcomes and reduces clinical symptoms in children with recurrent febrile convulsions,and the therapy has a high degree of efficacy and safety,with no significant improvement in immune function.