清肺通络汤对支原体肺炎患儿血清维生素A、维生素D及免疫功能的影响

Effects of Qingfei Tongluo Decoction on Serum Vitamin A,Vitamin D,and Immune Function in Children with Mycoplasma Pneumonia

目的:分析清肺通络汤对支原体肺炎患儿血清维生素A、维生素D及免疫功能的影响。方法:选取2019年1月至2020年12月上海交通大学附属第六人民医院收治的支原体肺炎患儿180例作为研究对象,根据治疗方案的不同将180例患儿分为观察组和对照组,每组90例。对照组患儿服用常规西药(阿奇霉素)进行医治,观察组患儿在服用阿奇霉素的基础上服用清肺通络汤医治,比较2组患者治疗效果,临床相关指标、免疫功能、血清维生素A和维生素D含量以及中医证候积分。结果:1)观察组患儿的治疗有效率显著高于对照组(P<0.05);2)观察组患者的退热时间、肺啰音消失时间、肺部阴影消失时间以及住院时间均明显低于对照组(P<0.05);3)观察组患儿治疗后的CD3^(+)、CD4^(+)水平显著高于同期对照组患儿的CD3^(+)、CD4^(+)水平(P<0.05);4)观察组患儿治疗后的血清维生素A、维生素D含量优于同期对照组患儿的血清维生素A、维生素D含量(P<0.05);5)治疗后,观察组患儿中医证候积分明显低于对照组(P<0.05);6)观察组患儿的不良反应发生率(25.56%)低于对照组患儿的不良反应发生率(13.33%),差异有统计学意义(P<0.05)。结论:服用清肺通络汤治疗,能够提高支原体肺炎患儿的免疫功能,对中医证候积分改善效果较为明显,不良反应较少,具有较好的临床疗效。

Objective:To analyze the effects of Qingfei Tongluo Decoction(QFTL)on serum vitamin A,vitamin D,and immune function in children with mycoplasma pneumonia.Methods:A total of 180 children with mycoplasma pneumonia treated in the Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University from January 2019 to December 2020 were enrolled and randomly divided into a control group(n=90)and an observation group(n=90)according to different treatment protocols.All children were treated with conventional western medicine(azithromycin),while those in the observation group received additional QFTL.The therapeutic effects,clinical relevant indicators,immune functions,serum levels of vitamin A and vitamin D,and traditional Chinese medicine(TCM)syndrome scores of the two groups were compared.Results:1)The effective rate in the observation group was higher than that in the control group(P<0.05).2)The antipyretic time,the disappearance time of lung rales,the disappearance time of lung shadow,and the hospitalization time of the observation group were shorter than those of the control group(P<0.05).3)After treatment,CD3^(+)and CD4^(+)in the observation group were higher than those in the control group(P<0.05).4)After treatment,the serum levels of vitamin A and vitamin D of the observation group were superior to those in the control group(P<0.05).5)The TCM syndrome scores of children in the observation group were lower than those in the control group(P<0.05).6)The incidence of adverse reactions in the observation group was 25.56%,lower than 13.33%in the control group(P<0.05).Conclusion:QFTL can enhance the immune function of the children with mycoplasma pneumonia and improve the TCM syndrome scores,with few adverse reactions and good clinical efficacy.