高压氧治疗急性缺血性脑卒中临床观察

Clinical observation of hyperbaric oxygen therapy for acute ischemic stroke

目的观察高压氧治疗急性缺血性脑卒中疗效及对生活质量的影响。方法94例患者随机分为对照组和观察组各47例,对照组接受常规治疗,观察组加用高压氧治疗,10 d为一疗程。比较2组临床疗效和梗死面积,分别采用美国国立卫生研究院卒中量表(NIHSS)、改良Rankin量表(mRS)、Barthel指数(BI)评价临床神经功能缺损、预后功能残疾水平和日常生活能力,脑卒中专门化生存质量量表(SS-QOL)评价生活质量,记录不良反应。结果观察组临床有效率为89.4%,高于对照组的70.2%(P<0.05)。治疗后,2组NIHSS、mRS评分和梗死面积显著降低,BI评分及SS-QOL量表评分显著增加(P<0.05);组间相比,观察组NIHSS、mRS评分和梗死面积低于对照组,BI评分,SS-QOL量表中语言、活动能力、情绪、自理、思维、总分高于对照组(P<0.05)。治疗过程无明显不良反应出现。结论高压氧治疗急性缺血性脑卒中疗效肯定,安全性好,且可提高患者生活质量。

Objective To observe the clinical efficacy of hyperbaric oxygen therapy(HBOT)for patients with acute ischemic stroke(AIS)and the impacts on quality of life.Methods Ninety-four patients with AIS were randomly divided into control group(n=47)and study group(n=47).The patients in control group received conventional treatment,the ones in study group received HBOT on the basis of control group.The treatment course in the two groups were both 10 days.The clinical efficacy and infarct size were compared,National Institute of Health Stroke Scale score(NIHSS),modified Rankin scale(mRS)and Barthel index(BI)were used to assess the neurological function impairment,extent of disability in prognosis and activity of daily living,respectively.SS-QOL scale was used to evaluate the quality of life.The adverse reactions were recorded.Results The clinical efficiency was 89.4%in the study group,which was higher than that of control group(70.2%,P<0.05).After treatment,NIHSS score,mRS score and infarct size decreased,BI and SS-QOL scores increased in both groups(P<0.05).Compared with the control group,the NIHSS score,mRS score and infarct size were lower,while BI score and the scores of language,activity,emotion,self-care,thinking and total score of SS-QOL scale were higher in study group(P<0.05).No obvious adverse reactions were noted in both groups.Conclusion HBOT is effective and safe for patients with AIS,and could improve the quality of life.