光热治疗在口腔鳞状细胞癌治疗中的研究进展

Research progress on the use of photothermal therapy to treat oral squamous cell carcinoma

目前,对于口腔鳞状细胞癌(OSCC)临床应用和研究较多的治疗手段主要包括手术、放射治疗、化学治疗、传统热疗、基因疗法、免疫疗法和光动力疗法(PDT)等,但治疗效果有限并伴有不同程度的不良反应。光热治疗(PTT)是一种新型的治疗方法,通过光热效应选择性杀伤癌细胞,具有较高的安全性。近红外光(NIR)具有良好的组织穿透性,光热转换剂(PTCA)具有可修饰性和选择性,它们是光热治疗的两大要素。通过构建纳米载体平台,PTT可协同增强其他治疗手段的疗效并降低不良反应。本文对OSCC的治疗现状、PTT的光热转换原理及在OSCC的治疗等方面进行综述,旨在为PTT在OSCC中的治疗提供理论依据。

At present,the most clinically applied and researched treatments for oral squamous cell carcinoma(OSCC)mainly include surgery,radiotherapy,chemotherapy,traditional hyperthermia,gene therapy,immunotherapy,and photodynamic therapy.However,the therapeutic effect of these treatments is limited and often accompanied by varying degrees of side effects.Photothermal therapy(PTT)is a novel type of treatment method that can selectively kill cancer cells through photothermal effect with high safety.The two elements of PTT are near infrared with good tissue penetration and photothermal conversion agents with modifiability and selectivity.By building nanocarrier platforms,PTT can synergistically enhance the efficacy of other therapies and reduce their side effects.In this paper,the current treatment status of OSCC,the photothermal conversion principle of PTT,and its application in the treatment of OSCC were reviewed to provide a theoretical basis for the treatment of OSCC using PTT.