乳牙牙髓干细胞在口腔组织再生修复中的研究进展

Research progress on the stem cells from human exfoliated deciduous teeth in the regeneration and repair of oral tissue

乳牙牙髓干细胞(SHED)是从脱落乳牙残留牙髓中提取的一种牙源性干细胞,其容易获取、储存和培养,并具有自我更新和多向分化等优异性能,与其他间充质干细胞相比优势明显。新近研究中,运用SHED的干细胞治疗已经在多种口腔组织再生修复中获得良好的疗效。本文阐述了SHED的干性维持与分化调控及其在干细胞治疗中的优势,并针对SHED在牙髓-牙本质复合体再生、牙周组织再生、骨再生、神经保护和免疫调节方面的研究进展作一综述。

Stem cells from human exfoliated deciduous teeth(SHEDs)are a kind of dental stem cells extracted from the residual pulp of deciduous teeth.They are easy to obtain,store,and culture and have excellent self-renewal as well as multidirectional differentiation.SHEDs have obvious advantages compared with other mesenchymal stem cells.In recent studies,stem cell therapy using SHEDs has achieved good results in the regeneration and repair of a variety of oral tissues.This article describes the stemness maintenance and differentiation regulation of SHEDs and their advantages in stem cell therapy.Moreover,it reviews the research progress on SHEDs in pulp-dentin complex regeneration,periodontal tissue regeneration,bone regeneration,neuroprotection,and immune regulation.