原发性肝癌患者合并压疮感染的危险因素研究

Study on risk factors of pressure ulcer infection in patients with primary hepatocellular carcinoma

目的探究原发性肝癌患者合并压疮感染的危险因素。方法回顾性分析广州市红十字会医院2019年12月~2021年10月收治的128例原发性肝癌患者,根据是否发生压疮感染分为压疮感染组和非压疮感染组。采用单因素分析和多因素logistic回归分析发生压疮感染的危险因素。结果128例原发性肝癌患者中发生压疮感染患者50例(压疮感染组),发生率为39.07%;78例患者未发生压疮感染(非压疮感染组),发生率为60.93%。单因素分析显示,压疮感染组年龄≥60岁、体质量指数(BMI)≥25 kg/m^(2)、糖尿病、机械通气、ICU住院天数≥14 d、KPS评分≤30分、Barden评分≤16分、血清白蛋白≤30 g/L、血红蛋白≤80 g/L、血清肿瘤坏死因子-α≥10 pg/ml占比显著高于非压疮感染组,差异有统计学意义(P<0.05)。多因素logistic回归分析证实,年龄≥60岁、BMI≥25 kg/m^(2)、糖尿病、机械通气、ICU住院天数≥14 d、KPS评分≤30分、Barden评分≤16分、血清白蛋白≤30 g/L、血红蛋白≤80 g/L、血清肿瘤坏死因子-α≥10 pg/ml是原发性肝癌患者压疮感染的独立危险因素,差异有统计学意义(P<0.05)。结论原发性肝癌患者压疮感染的危险因素不仅与年龄、BMI、糖尿病、机械通气、ICU住院天数、KPS评分、Barden评分有关,还与血清白蛋白水平、血红蛋白水平、血清肿瘤坏死因子-α水平有关,临床应尽早识别这些危险因素并采取针对性预防措施。

Objective To explore the risk factors of pressure ulcers infection in patients with primary liver cancer.Methods The clinical data of 128 patients with primary liver cancer admitted to our hospital from December 2019 to October 2021 were retrospectively analyzed,according to the occurrence of pressure ulcer infection is divided into pressure ulcer infection group and non pressure ulcer infection group.Univariate analysis and multivariate logistic regression were used to analyze the risk factors of pressure ulcers infection.Results In 128 patients with primary liver cancer,50 patients were infected with pressure ulcers(39.07%);78 patients did not develop pressure ulcer infection(non-pressure ulcer infection group),the incidence was 60.93%.Univariate analysis showed that the pressure ulcer infection group was older than 60 years old,BMI>25 kg/m^(2),diabetes,mechanical ventilation,ICU hospitalization days were more than 14 d,KPS score was less than 30 points,Barden score was less than 16 points,serum albumin was less than 30 g/L,hemoglobin was less than 80 g/L,serum tumor necrosis factor-αThe proportion of≥10 pg/ml was significantly higher than that in non pressure ulcer infection group(P<0.05).Multivariate logistic regression analysis confirmed that Age≥60 years,BMI≥25 kg/m^(2),diabetes mellitus,mechanical ventilation,ICU stay≥14 days,KPS score≤30,Barden score≤16,serum albumin≤30 g/L,hemoglobin≤80 g/L,serum tumor necrosis factor-α≥10 Pg/mL was an independent risk factor for pressure ulcer infection in patients with primary liver cancer(P<0.05).Conclusion Risk factors for primary liver cancer patients with pressure ulcers infection more,not only with age,BMI,diabetes,mechanical ventilation,ICU hospitalization days,KPS score,Barden score,also with serum albumin levels,hemoglobin level,serum tumor necrosis factor alpha levels,we should recognize these clinical risk factors earlierly and take corresponding preventive measures.