原发性颅内多发外周T细胞淋巴瘤1例并文献复习

Multiple intracranial primary peripheral T-cell lymphoma:a case report and literature review

目的探讨原发性颅内多发外周T细胞淋巴瘤的诊断与治疗方法。方法回顾性分析1例原发性颅内多发外周T细胞淋巴瘤患者的临床资料,并复习相关文献。结果患者有10年抑郁症病史,误诊为脑炎,头颅MR检查示,左侧额顶颞枕岛叶、左侧基底节区多发斑片状信号影,后通过手术活检进行病理学及分子学诊断后确诊,术后患者及家属放弃接受放化疗方案,随访6个月后死亡。结论颅内多发外周T细胞淋巴瘤较为罕见,临床表现不明显,影像学检查容易误诊,诊断主要靠手术活检并进行病理学和分子学检查的方法确诊,诊断明确后进行放疗和化疗是延长患者生存期的主要方法。

Objective To investigate the diagnosis and treatment of multiple intracranial primary peripheral T-cell lymphoma. Methods The clinical data of 1 patient with multiple intracranial primary peripheral T-cell lymphoma were retrospectively analyzed, and the relevant literature was reviewed. Results The patient had a history of depression for 10 years and was misdiagnosed as encephalitis. Cranial MR examination showed multiple patchy signal shadows in the left frontotemporal occipital insula and the left basal ganglia region. The diagnosis was made after pathological and molecular diagnosis by surgical biopsy. The patients and their families gave up receiving chemoradiotherapy and died after 6 months of follow-up. Conclusions Intracranial multiple peripheral T-cell lymphoma is relatively rare, and the clinical manifestations are not obvious. Imaging examination is prone to misdiagnosis. The diagnosis is mainly confirmed by surgical biopsy and pathological and molecular examination, and radiotherapy and chemotherapy after the diagnosis is clear is the main method to prolong the patient’s survival.