柊叶对急性酒精中毒小鼠解酒作用的研究

Study on hangover effect of Phrynium capitayum willd on mice with acute alcoholism

目的:探讨柊叶对急性酒精中毒小鼠的解酒作用。方法:采用酒精灌胃法建立小鼠急性酒精中毒模型,观察各组小鼠醉酒行为学指标,记录各组小鼠醉酒时间和醒酒时间,采用气相色谱法测定各组小鼠血清中乙醇浓度。结果:与模型组小鼠的醉酒持续时间相比,阳性对照组、柊叶叶组、柊叶花组、柊叶根组小鼠的醉酒持续时间明显缩短。且与模型组、阳性对照组小鼠的血清乙醇含量比较,柊叶提取物组小鼠的血清中乙醇浓度显著降低。由此可见,柊叶能显著缩短小鼠醉酒时长,降低小鼠血清乙醇浓度,解酒效果明显,差异均有统计学意义。结论:柊叶对急性酒精中毒的小鼠能快速发挥解酒作用。

Objective:To explore the effects of Phrynium capitayum willd on the hangover of mice with acute alcoholism.Methods:The acute alcoholism model of mice was established by the method of alcohol gavage.The behavioral indicators of drunkenness of mice in each group were observed,the drunkenness time and sober up time of mice in each group were recorded,the concentration of ethanol in serum of mice in each group was measured by gas chromatography.Results:Compared with the mice in the model group,the duration of drunkennessin the positive control group,the leaf group of Phrynium capitayum willd,the flower group of phrynium capitayum Willd,and the root group of Phrynium capitayum willd mice were significantly shortened.And compared with the serum ethanol content of the mice in the model group and the positive control group,the ethanol concentration in the serum of the mice in the Phrynium capitayum will dextract group was significantly reduced.It could be seen that the Phrynium capitayum willd could significantly shorten the duration of drunkenness of the mice,reduce the serum ethanol concentration of the mice,and have a significant effect of hangover,The differences are statistically significant.Conclusion:Phrynium capitayum willd can quickly play the role of hangover in mice with acute alcoholism.