血清HK-10、RBP表达与卵巢癌盆腔转移的相关性

Correlation of expression of serum HK-10 and RBP with pelvic metastasis of ovarian cancer

目的分析血清人激肽释放酶10(HK-10)、视黄醇结合蛋白(RBP)水平与卵巢癌盆腔转移的关系。方法抽取2017年1月至2018年10月于河南省直第三人民医院接受腹腔镜手术治疗的53例卵巢癌患者,以盆腔转移作为终点事件,依据术后是否发生盆腔转移分为发生组与未发生组。接受腹腔镜手术治疗前调查两组一般资料,检测并比较两组实验室指标,重点分析血清HK-10、RBP与患者盆腔转移的关系。结果 53例接受腹腔镜手术治疗的卵巢癌患者,经随访,发生盆腔转移27例(50.94%,27/53)。发生组血清人附睾蛋白4(HE4)、血管内皮生长因子(VEGF)、HK-10、RBP水平均高于未发生组(P均<0.05),组间其他资料比较差异未见统计学意义(P>0.05)。回归分析结果显示,治疗前血清HE4、VEGF、HK-10、RBP水平与卵巢癌患者发生盆腔转移有关,各指标过表达可能是卵巢癌患者发生盆腔转移的风险因子(OR>1,P<0.05);绘制受试者工作特征曲线结果显示,治疗前血清HE4、VEGF、HK-10、RBP预测卵巢癌患者发生盆腔转移风险的曲线下面积均>0.80,且治疗前血清HE4、VEGF、HK-10、RBP的最佳截断值分别为211.711 pmol/L、229.393 pg/ml、1.340 mg/L、15.661 ng/ml时的预测价值最佳;相关性分析结果显示,卵巢癌患者治疗前血清HK-10水平与RBP水平之间呈正相关(r>0,P<0.05)。结论血清HK-10、RBP水平与卵巢癌患者发生盆腔转移有关,可能是患者发生盆腔转移的风险因子,对预测患者发生盆腔转移风险有一定价值。

Objective To analyze the relationship of serum human kallikrein 10(HK-10)and retinol binding protein(RBP)levels with pelvic metastasis of ovarian cancer.Methods Fifty-three patients with ovarian cancer who received laparoscopic surgery for treatment in the Third People’s Hospital of Henan Province from January 2017 to October 2018 were selected,and the end point was pelvic metastasis.According to the occurrence of pelvic metastasis after operation,the patients were divided into occurrence group and non occurrence group.The general data of the two groups were investigated before laparoscopic surgery.The laboratory indexes of the two groups were detected and compared,the relationship of expression of HK-10 and RBP with pelvic metastasis was mainly analyzed.Results Among the 53 patients with ovarian cancer treated by laparoscopic surgery,27 patients(50.94%,27/53)had pelvic metastasis during follow-up.The serum human epididymal protein 4(HE4),vascular endothelial growth factor(VEGF),HK-10 and RBP levels in the occurrence group were higher than those in the non occurrence group(all P<0.05);there was no statistically significant difference in other data between the two groups(P>0.05).The results of regression analysis showed that serum levels of HE4,VEGF,HK-10 and RBP before treatment were related to pelvic metastasis in patients with ovarian cancer,while overexpression of each index might be a risk factor for pelvic metastasis in patients with ovarian cancer(OR>1,P<0.05).Results of the receiver operating characteristic curve showed that the area under the curve of serum HE4,VEGF,HK-10 and RBP before treatment in predicting the risk of pelvic metastasis in ovarian cancer patients were all>0.80,and when the cut-off values of serum HE4,VEGF,HK-10 and RBP were 211.711 pmol/L,229.393 pg/ml,1.340 mg/L and 15.661 ng/ml,respectively,before treatment,the predictive value was the best;the results of correlation analysis showed that serum HK-10 level was positively correlated with RBP level(r>0,P<0.05).Conclusions Serum HK-10 and RBP levels are related to pelvic metastasis in ovarian cancer patients,which may be risk factors for pelvic metastasis in patients.They have certain value in predicting the risk of pelvic metastasis in patients.