宫颈癌患者血清CEA、CA125、CA199、HE4水平及其临床意义

Expression levels and clinical significance of serum CEA,CA125,CA199 and HE4 in patients with cervical cancer

目的分析宫颈癌患者血清癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原199(CA199)、人附睾蛋白4(HE4)水平及其临床意义。方法抽取2019年11月至2021年11月郑州市妇幼保健院收治的宫颈癌患者98例作为宫颈癌组,并以1∶1配比抽取同期收治的98例宫颈癌前病变患者作为癌前病变组、98例健康体检者作为健康对照组。检测三组受试对象的CEA、CA125、CA199、HE4水平,比较三组和宫颈癌组不同分期、不同分化程度、不同浸润深度患者血清CEA、CA125、CA199、HE4表达水平,比较宫颈癌不同分期患者各指标阳性检出率,分析相关性。结果宫颈癌组CEA、CA125、CA199、HE4表达水平均高于癌前病变组和健康对照组(P均<0.05);宫颈癌组中Ⅲ~Ⅳ期、低分化、深肌层浸润患者CEA、CA125、CA199、HE4水平均高于Ⅰ~Ⅱ期、高分化、中分化和浅肌层浸润患者(P<0.05)。宫颈癌Ⅲ~Ⅳ期患者CEA、CA125、CA199、HE4单独检测的阳性率均高于Ⅰ~Ⅱ期患者,宫颈癌Ⅰ~Ⅱ期患者四者联合检测的阳性率高于单独检测(P<0.05)。Pearson分析结果显示,血清CEA、CA125、CA199、HE4水平和宫颈癌分期、浸润深度呈正相关,和宫颈癌分化程度呈负相关(P<0.05)。结论宫颈癌患者血清CEA、CA125、CA199、HE4水平显著升高,并与病理特征密切相关,在宫颈癌早期采用联合检测具有较高阳性率,可为临床早期诊疗提供依据。

Objective To analyze the expression levels and clinical significance of serum carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA199),and human epididymis protein 4(HE4)in patients with cervical cancer.Methods A total of 98 patients with cervical cancer treated in Zhengzhou Maternial and Child Health Hospital from November 2019 to November 2021 were selected as the cervical cancer group,and 98 patients with premalignant lesion in the same period were selected as the premalignant lesion group,while 98 persons who underwent healthy physical examination were selected as the healthy control group.The levels of CEA,CA125,CA199 and HE4 of the three groups were detected.The expression levels of serum factors in the three groups and in patients with different stages,different degrees of differentiation and different depth of invasion in the cervical cancer group were compared.The positive detection rates of various factors in different stages were compared,and the correlation was analyzed.Results The expression levels of CEA,CA125,CA199 and HE4 in cervical cancer group were higher than those in premalignant lesion group and healthy control group(P<0.05).The levels of CEA,CA125,CA199 and HE4 in patients with stageⅢ-Ⅳ,low differentiation and deep muscle infiltration were higher than those in patients with stageⅠ-Ⅱ,high differentiation,medium differentiation and shallow muscle infiltration(P<0.05).The positive rates of CEA,CA125,CA199,and HE4 separate tests in patients with stage III to IV were higher than those in patients with stage I to II,and the positive rate of combined detection in patients with stageⅠ-Ⅱwas higher than that of separate test(P<0.05).Pearson analysis showed that the levels of serum CEA,CA125,CA199,HE4 were positively correlated with stage and depth of invasion of cervical cancer.The levels of serum CEA,CA125,CA199 and HE4 were negatively correlated with the degree of differentiation of cervical cancer(P<0.05).Conclusions Serum CEA,CA125,CA199 and HE4 levels of cervical cancer are significantly increased,which is closely related to pathological features.The combined detection in the early stage of cervical cancer has a higher positive rate,which can provide a basis for early clinical diagnosis and treatment.